Demeler, Borries

 

Recent Submissions

  • Williams, Taylor L.; Gorbet, Gary E.; Demeler, Borries (SpringerArts and ScienceDepartment of Chemistry and BiochemistryUniversity of Texas Health Science Center at San AntonioUniversity of Lethbridgehttps://doi.org/10.1007/s00249-018-1297-z, 2018)
    A framework for the global analysis of multi-speed analytical ultracentrifugation sedimentation velocity experiments is presented. We discuss extensions to the adaptive space–time finite element fitting methods implemented ...
  • Nelson, Corey R.; Mrozowich, Tyler; Park, Sean M.; D'souza, Simmone; Henrickson, Amy; Vigar, Justin R. J.; Wieden, Hans-Joachim; Owens, Raymond J.; Demeler, Borries; Patel, Trushar R. (MDPIArts and ScienceDepartment of Chemistry and BiochemistryUniversity of LethbridgeUniversity of CalgaryRutherford Appleton LaboratoriesUniversity of MontanaUniversity of Albertahttps://doi.org/10.3390/ijms22010054, 2020)
    Rift Valley fever virus (RVFV) is a mosquito-transmitted virus from the Bunyaviridae family that causes high rates of mortality and morbidity in humans and ruminant animals. Previous studies indicated that DEAD-box helicase ...
  • Gray, Felicia; Cho, Hyo Je; Shukla, Shirish; He, Shihan; Harris, Ashley; Boytsov, Bohdan; Jaremko, Lukasz; Jaremko, Mariusz; Demeler, Borries; Lawlor, Elizabeth R.; Grembecka, Jolanta; Cierpicki, Tomasz (Nature PublishingArts and ScienceDepartment of Chemistry and BiochemistryUniversity of MichiganMax-Planck Institute of Biophysical ChemistryUniversity of Texas Health Science Center at San AntonioUniversity of Lethbridgehttps://doi.org/10.1038/ncomms13343, 2016)
    BMI1 is a core component of the polycomb repressive complex 1 (PRC1) and emerging data support a role of BMI1 in cancer. The central domain of BMI1 is involved in protein–protein interactions and is essential for its ...
  • Fan, Yanlin; Guo, Yusong R.; Yuan, Wang; Zhou, Ying; Holt, Matthew V.; Wang, Tao; Demeler, Borries; Young, Nicolas L.; Zhong, Weiwei; Tao, Yizhi J. (Public Library of ScienceArts and ScienceDepartment of Chemistry and BiochemistryRice UniversityBaylor College of MedicineUniversity of Texas Health Science Center at San AntonioUniversity of Lethbridgehttps://doi.org/10.1371/journal.ppat.1006231, 2017)
    Despite the wide use of Caenorhabditis elegans as a model organism, the first virus naturally infecting this organism was not discovered until six years ago. The Orsay virus and its related nematode viruses have a ...
  • Stoutjesdyk, Marielle; Henrickson, Amy; Minors, Geoff; Demeler, Borries (SpringerArts and ScienceDepartment of Chemistry and BiochemistryUniversity of Lethbridgehttps://doi.org/10.1007/s00249-020-01434-z, 2020)
    Experiments performed in the analytical ultracentrifuge (AUC) measure sedimentation and diffusion coefficients, as well as the partial concentration of colloidal mixtures of molecules in the solution phase. From this ...
  • Stoutjesdyk, Marielle; Brookes, Emre; Henrickson, Amy; Demeler, Borries (SpringerArts and ScienceDepartment of Chemistry and BiochemistryUniversity of Lethbridgehttps://doi.org/10.1007/s00249-020-01482-5, 2020)
    A method is described to accurately measure the compressibility of liquids using an analytical ultracentrifuge. The method makes use of very large pressure gradients, which can be generated in the analytical ultracentrifuge ...
  • Wang, Zhonghua; Bhattacharya, Akash; White, Tommy; Buffone, Cindy; McCabe, Aine; Nguyen, Laura A.; Shepard, Caitlin N.; Pardo, Sammy; Kim, Baek; Weintraub, Susan T.; Demeler, Borries; Diaz-Griffero, Felipe; Ivanov, Dmitri N. (Cell PressArts and ScienceDepartment of Chemistry and BiochemistryUniversity of Texas Health Science CenterAlbert Einstein College of MedicineEmory School of MedicineKyunghee UniversityUniversity of Lethbridgehttps://doi.org/10.1016/j.celrep.2018.06.090, 2018)
    SAMHD1 is a dNTP triphosphohydrolase (dNTPase)that impairs retroviral replication in a subset of non-cycling immune cells. Here we show that SAMHD1is a redox-sensitive enzyme and identify threeredox-active cysteines within ...
  • Adusei-Danso, Felix; Khaja, Faisal Tarique; DeSantis, Micaela; Jeffrey, Philip D.; Dubnau, Eugenie; Demeler, Borries; Neiditch, Matthew B.; Dubnau, David (American Society for MicrobiologyArts and ScienceDepartment of Chemistry and BiochemistryRutgers UniversityCenter of New Jersey Medical SchoolPrinceton UniversityUniversity of Lethbridgehttps://doi.org/10.1128/mBio.01841-19, 2019)
    In Bacillus subtilis, the RicA (YmcA), RicF (YlbF), and RicT (YaaT) proteins accelerate the phosphorylation of the transcription factor Spo0A, contributing to ge netic competence, sporulation, and biofilm formation, and ...
  • Mrozowich, Tyler; Henrickson, Amy; Demeler, Borries; Patel, Trushar R. (MDPIArts and ScienceDepartment of Chemistry and BiochemistryUniversity of LethbridgeUniversity of MontanaUniversity of CalgaryUniversity of Albertahttps://doi.org/10.3390/v12020190, 2020)
    Viral infections are responsible for numerous deaths worldwide. Flaviviruses, which contain RNA as their genetic material, are one of the most pathogenic families of viruses. There is an increasing amount of evidence ...
  • Obi, Juliet O.; Lubula, Mulu Y.; Cornilescu, Gabriel; Henrickson, Amy; McGuire, Kara; Evans, Chiara M.; Phillips, Margaret; Boyson, Samuel P.; Demeler, Borries; Markley, John L.; Glass, Karen C. (ElsevierArts and ScienceDepartment of Chemistry and BiochemistryAlbany College of Pharmacy and Health SciencesUniversity of Wisconsin-MadisonUniversity of Lethbridgehttps://doi.org/10.1016/j.crstbi.2020.05.001, 2020)
    Bromodomain-containing proteins are often part of chromatin-modifying complexes, and their activity can lead toaltered expression of genes that drive cancer, inflammation and neurological disorders in humans. Bromodomain-PHDfinger ...
  • Yu, Corey H.; Bhattacharya, Akash; Persaud, Mirjana; Taylor, Alexander B.; Wang, Zhonghua; Bulnes-Ramos, Angel; Xu, Joella; Selyutina, Anastasia; Martinez-Lopez, Alicia; Cano, Kristin; Demeler, Borries; Kim, Baek; Hardies, Stephen C.; Diaz-Griffero, Felipe; Ivanov, Dmitri N. (Nature Publishing GroupArts and ScienceDepartment of Chemistry and BiochemistryUT Health San AntonioAlbert Einstein College of MedicineEmory School of MedicineUniversity of LethbridgeUniversity of Montanahttps://doi.org/10.1038/s41467-021-21023-8, 2021)
    SAMHD1 impedes infection of myeloid cells and resting T lymphocytes by retroviruses, and the enzymatic activity of the protein—dephosphorylation of deoxynucleotide triphosphates (dNTPs)—implicates enzymatic dNTP depletion ...
  • Horne, Christoper R.; Venugopal, Hariprasad; Panjikar, Santosh; Wood, David M.; Henrickson, Amy; Brookes, Emre; North, Rachel A.; Murphy, James M.; Friemann, Rosmarie; Griffin, Michael D. W.; Ramm, Georg; Demeler, Borries; Dobson, Renwick C. J. (Nature Publishing GroupArts and ScienceDepartment of Chemistry and BiochemistryUniversity of CenterburyMonash UniversityUniversity of LethbridgeUniversity of MontanaUniversity of MelbourneSahlgrenska University HospitalUniversity of Gothenburghttps://doi.org/10.1038/s41467-021-22253-6, 2021)
    Bacteria respond to environmental changes by inducing transcription of some genes and repressing others. Sialic acids, which coat human cell surfaces, are a nutrient source for pathogenic and commensal bacteria. The ...
  • Savelyev, Alexey; Gorbet, Gary E.; Henrickson, Amy; Demeler, Borries (Public Library of ScienceArts and ScienceDepartment of Chemistry and BiochemistryUniversity of MontanaAUC SolutionsUniversity of Lethbridgehttps://doi.org/10.1371/journal.pcbi.1007942, 2020)
    Recent advances in instrumentation have moved analytical ultracentrifugation (AUC) closer to a possible validation in a Good Manufacturing Practices (GMP) environment. In order for AUC to be validated for a GMP environment, ...