Investigating the behavioural impacts of chronic high-CBD cannabis consumption in adolescent Long-Evans rats

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Giddy, Melissa Leanne
University of Lethbridge. Faculty of Arts and Science
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Lethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciences
Cannabis sativa, or ‘cannabis’, is an herbaceous plant that possesses hallucinogenic and medicinal properties. The primary constituents found within cannabis are CBD and THC, both of which are capable of eliciting behavioural and physiological effects in mammals. CBD has shown promise in controlling the adverse effects of THC. THC and CBD together have shown promising synergistic and medicinal effects. With the increased use of cannabis as a medicine, it is imperative we determine the safety of consumption in an adolescence. Using two high-CBD cannabis extracts at two dosing levels, adolescent animals were dosed for 14 days. Following dosing, animals were tested on a behavioural test battery looking for altered anxiety and learning and memory skills. Overall, there were no major impacts of sex, treatment or Treatment x Sex Differences in behaviour. In conclusion, there are no lasting behavioural impacts of consuming high-CBD cannabis extract.
behaviour , cannabis , chronic high-CBD consumption in adolescence , adolescent behavioural development , cannabinoids , Cannabis--Therapeutic use--Research , Cannabinoids--Therapeutic use--Research , Cannabinoids--Physiological effect--Research , Rats as laboratory animals , Rats--Infancy--Effect of drugs on--Research , Rats--Infancy--Behavior--Effect of drugs on--Research , Cannabinoids--Psychological aspects--Research , Dissertations, Academic