Investigating the behavioural impacts of chronic high-CBD cannabis consumption in adolescent Long-Evans rats

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dc.contributor.authorGiddy, Melissa Leanne
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorGibb, Robbin L.
dc.contributor.supervisorKovalchuk, Igor
dc.date.accessioned2022-07-07T17:55:12Z
dc.date.available2022-07-07T17:55:12Z
dc.date.issued2022
dc.degree.levelMastersen_US
dc.description.abstractCannabis sativa, or ‘cannabis’, is an herbaceous plant that possesses hallucinogenic and medicinal properties. The primary constituents found within cannabis are CBD and THC, both of which are capable of eliciting behavioural and physiological effects in mammals. CBD has shown promise in controlling the adverse effects of THC. THC and CBD together have shown promising synergistic and medicinal effects. With the increased use of cannabis as a medicine, it is imperative we determine the safety of consumption in an adolescence. Using two high-CBD cannabis extracts at two dosing levels, adolescent animals were dosed for 14 days. Following dosing, animals were tested on a behavioural test battery looking for altered anxiety and learning and memory skills. Overall, there were no major impacts of sex, treatment or Treatment x Sex Differences in behaviour. In conclusion, there are no lasting behavioural impacts of consuming high-CBD cannabis extract.en_US
dc.description.sponsorshipMITACSen_US
dc.identifier.urihttps://hdl.handle.net/10133/6259
dc.language.isoen_USen_US
dc.proquest.subject0317en_US
dc.proquest.subject0384en_US
dc.proquest.subject0620en_US
dc.proquestyesYesen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciencesen_US
dc.publisher.departmentDepartment of Biological Sciencesen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectbehaviouren_US
dc.subjectcannabisen_US
dc.subjectchronic high-CBD consumption in adolescenceen_US
dc.subjectadolescent behavioural developmenten_US
dc.subjectcannabinoidsen_US
dc.subjectCannabis--Therapeutic use--Researchen_US
dc.subjectCannabinoids--Therapeutic use--Researchen_US
dc.subjectCannabinoids--Physiological effect--Researchen_US
dc.subjectRats as laboratory animalsen_US
dc.subjectRats--Infancy--Effect of drugs on--Researchen_US
dc.subjectRats--Infancy--Behavior--Effect of drugs on--Researchen_US
dc.subjectCannabinoids--Psychological aspects--Researchen_US
dc.subjectDissertations, Academicen_US
dc.titleInvestigating the behavioural impacts of chronic high-CBD cannabis consumption in adolescent Long-Evans ratsen_US
dc.typeThesisen_US
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