Microscale thermophoresis: warming up to a new biomolecular interaction technique

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dc.contributor.authorMrozowich, Tyler
dc.contributor.authorMeier-Stephenson, Vanessa
dc.contributor.authorPatel, Trushar R.
dc.date.accessioned2024-08-02T19:41:27Z
dc.date.available2024-08-02T19:41:27Z
dc.date.issued2019
dc.descriptionOpen access article. Creative Commons Attribution NonCommercial-NoDerivatives 4.0 International license (CC BY-NC-ND 4.0) aplies
dc.description.abstractBiomolecules, such as RNA, DNA, proteins and polysaccharides, are at the heart of fundamental cellular processes. These molecules differ greatly with each other in terms of their structures and functions. However, in the midst of the diversity of biomolecules is the unifying feature that they interact with each other to execute a viable biological system. Interactions of biomolecules are critical for cells to survive and replicate, for food metabolism to produce energy, for antibiotics and vaccines to function, for spreading of diseases and for every other biological process. An improved understanding of these interactions is crucial for studying how cells and organs function, to appreciate how diseases are caused and how infections occur, with infinite implications in medicine and therapy. Many biochemical and biophysical techniques are currently being employed to study biomolecular interactions. Microscale thermophoresis (MST) is a relatively new biophysical technique that can provide powerful insight into the interactions of biomolecules and is quickly being adopted by an increasing number of researchers worldwide. This article provides a brief description of principles underpinning the MST process, in addition to benefits and limitations.
dc.identifier.citationMrozowich, T., Meier-Stephenson, & Patel, T. R. (2019). Warming thermophoresis: Warming up to a new biomolecular interaction technique. Biochemist, 41(2), 8-12. https://doi.org/10.1042/BIO04102008
dc.identifier.urihttps://hdl.handle.net/10133/6833
dc.language.isoen
dc.publisherPortland Press
dc.publisher.departmentDepartment of Chemistry and Biochemistry
dc.publisher.facultyArts and Science
dc.publisher.institutionUniversity of Lethbridge
dc.publisher.institutionAlberta Health Services
dc.subjectMicroscale thermophoresis
dc.subjectBiomolecular interaction
dc.subjectBiomolecules
dc.subject.lcshBiomolecules--Analysis
dc.titleMicroscale thermophoresis: warming up to a new biomolecular interaction technique
dc.typeArticle
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