1H NMR metabolomics of stress

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Kiss, Douglas A.
University of Lethbridge. Faculty of Arts and Science
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Lethbridge, Alta : University of Lethbridge, Dept. of Neuroscience
Metabolomics provides a method to study the dynamics of cellular function by adopting a systems biology approach to the analysis of small molecule metabolites found in various bio-fluids and tissue locations. Chapters one and two of this thesis explore the theory behind metabolomics and reviews representative studies applying NMR metabolomics to neuroscience. Chapter three presents the results from an experiment investigating the alterations of metabolic by-products found in urine caused by both cumulative and remote ancestral prenatal maternal stress. Chapter four explores the results of a similar experiment where the liver tissue from offspring of either cumulative or remote ancestral prenatal maternal stress were analysed. Chapter five is a general discussion and conclusion of the results from both experiments and explores how both sets of results indicate an alteration in the stress response of the offspring.
metabolism , NMR spectroscopy , anxiety , depression , biomarker