1H NMR metabolomics of stress

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dc.contributor.authorKiss, Douglas A.
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorMetz, Gerlinde A. S.
dc.date.accessioned2016-09-22T17:27:28Z
dc.date.available2016-09-22T17:27:28Z
dc.date.issued2016
dc.degree.levelMastersen_US
dc.description.abstractMetabolomics provides a method to study the dynamics of cellular function by adopting a systems biology approach to the analysis of small molecule metabolites found in various bio-fluids and tissue locations. Chapters one and two of this thesis explore the theory behind metabolomics and reviews representative studies applying NMR metabolomics to neuroscience. Chapter three presents the results from an experiment investigating the alterations of metabolic by-products found in urine caused by both cumulative and remote ancestral prenatal maternal stress. Chapter four explores the results of a similar experiment where the liver tissue from offspring of either cumulative or remote ancestral prenatal maternal stress were analysed. Chapter five is a general discussion and conclusion of the results from both experiments and explores how both sets of results indicate an alteration in the stress response of the offspring.en_US
dc.embargoNoen_US
dc.identifier.urihttps://hdl.handle.net/10133/4610
dc.language.isoen_CAen_US
dc.proquestyesNoen_US
dc.publisherLethbridge, Alta : University of Lethbridge, Dept. of Neuroscienceen_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectmetabolismen_US
dc.subjectNMR spectroscopyen_US
dc.subjectanxietyen_US
dc.subjectdepressionen_US
dc.subjectbiomarkeren_US
dc.title1H NMR metabolomics of stressen_US
dc.typeThesisen_US
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