Transgenerational programming of brain and behaviour by prenatal stress
University of Lethbridge. Faculty of Arts and Science
Lethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience, c2013
Exposure to adverse environmental factors such as prenatal stress (PS) can have longlasting effects on brain health and disease. Through direct and transgenerational genetic and epigenetic influences on healthy development and aging, PS may promote adaptive developmental plasticity, but at the same time also lead to increased health risks. Ultimately, the main goal of this research was to determine if PS-associated alterations of the fetal developmental programing can be transmitted across generations to affect brain development and behaviour, and ultimately increase the susceptibility to disease throughout lifespan. Work in Chapter 2 showed sexually dimorphic effects of multigenerational prenatal stress on behavioural traits, laterality and hemispheric dominance in male and female rats. In Chapter 3, hair elementary analysis was shown to be a sensitive, comprehensive and accurate screening tool of age-related metabolic and overall health status. Chapter 4 determined the manifestations of PS on behavioural and physiological outcomes in aging male rats after exposure to PS in one generation (F1-PS) vs. multiple generations (F4-PS). These results provide evidence that PSassociated alterations of the fetal developmental programming may be transmitted across regenerations altering brain development and inducing behavioural disturbances throughout lifespan.
xii, 105 leaves ; 29 cm
Brain -- Effect of stress on , Prenatal influences , Stress (Physiology) , Rats -- Behavior , Dissertations, Academic