Transgenerational programming of brain and behaviour by prenatal stress

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dc.contributor.authorAmbeskovic, Mirela
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorMetz, Gerlinde A. S.
dc.date.accessioned2014-07-28T17:51:32Z
dc.date.available2014-07-28T17:51:32Z
dc.date.issued2013
dc.degree.levelMastersen_US
dc.degree.levelMasters
dc.descriptionxii, 105 leaves ; 29 cmen_US
dc.description.abstractExposure to adverse environmental factors such as prenatal stress (PS) can have longlasting effects on brain health and disease. Through direct and transgenerational genetic and epigenetic influences on healthy development and aging, PS may promote adaptive developmental plasticity, but at the same time also lead to increased health risks. Ultimately, the main goal of this research was to determine if PS-associated alterations of the fetal developmental programing can be transmitted across generations to affect brain development and behaviour, and ultimately increase the susceptibility to disease throughout lifespan. Work in Chapter 2 showed sexually dimorphic effects of multigenerational prenatal stress on behavioural traits, laterality and hemispheric dominance in male and female rats. In Chapter 3, hair elementary analysis was shown to be a sensitive, comprehensive and accurate screening tool of age-related metabolic and overall health status. Chapter 4 determined the manifestations of PS on behavioural and physiological outcomes in aging male rats after exposure to PS in one generation (F1-PS) vs. multiple generations (F4-PS). These results provide evidence that PSassociated alterations of the fetal developmental programming may be transmitted across regenerations altering brain development and inducing behavioural disturbances throughout lifespan.en_US
dc.identifier.urihttps://hdl.handle.net/10133/3467
dc.language.isoen_CAen_US
dc.proquestyesNoen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience, c2013en_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectBrain -- Effect of stress onen_US
dc.subjectPrenatal influencesen_US
dc.subjectStress (Physiology)en_US
dc.subjectRats -- Behavioren_US
dc.subjectDissertations, Academicen_US
dc.titleTransgenerational programming of brain and behaviour by prenatal stressen_US
dc.typeThesisen_US
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