The effects of Cannabis sativa extracts on human macrophages in vitro

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Zaiachuk, Mariia
University of Lethbridge. Faculty of Arts and Science
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Lethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciences
Inflammation is the immune system’s response to an injury due to any agent. Currently, there is a wide array of anti-inflammatory agents available; however, they cause numerous side effects which compromise patients’ quality of life. Therefore, new antiinflammatory agents and strategies are required. Multiple research articles have demonstrated the strong potential of Cannabis sativa extracts and their active ingredients, including cannabinoids and terpenes, to be used in the treatment of inflammatory disorders. The current study explores the immunomodulatory potential of cannabis extracts in vitro. We investigated how the extracts of selected novel cannabis cultivars influence the secretion of cytokines in lipopolysaccharide (LPS)-induced macrophages. We discovered that studied cannabis extracts significantly reduced the levels of cytokines, such as IL-1β, TNF-α, IL-6, IL-8, MCP-1, and IL-10, while not being cytotoxic to macrophages. This study may serve as a roadmap for the future analysis of the anti-inflammatory effects of medical cannabis in vivo.
immunomodulators , macrophages , cytokines , Cannabis sativa extracts , anti-inflammatory agents , inflammatory disorder treatments , Anti-inflammatory agents -- Research , Cannabis -- Therapeutic use -- Research , Plant extracts -- Therapeutic use -- Research , Botany, Medical , Medicinal plants -- Research , Materia medica, Vegetable , Cannabinoids -- Therapeutic use -- Research , Terpines -- Therapeutic use -- Research , Cytokines -- Research , Macrophages -- Research , Biological response modifiers , Immune response -- Regulation , Dissertations, Academic