The effects of Cannabis sativa extracts on human macrophages in vitro
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Date
2021
Authors
Zaiachuk, Mariia
University of Lethbridge. Faculty of Arts and Science
Journal Title
Journal ISSN
Volume Title
Publisher
Lethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciences
Abstract
Inflammation is the immune system’s response to an injury due to any agent.
Currently, there is a wide array of anti-inflammatory agents available; however, they cause
numerous side effects which compromise patients’ quality of life. Therefore, new antiinflammatory
agents and strategies are required. Multiple research articles have demonstrated
the strong potential of Cannabis sativa extracts and their active ingredients, including
cannabinoids and terpenes, to be used in the treatment of inflammatory disorders. The current
study explores the immunomodulatory potential of cannabis extracts in vitro. We investigated
how the extracts of selected novel cannabis cultivars influence the secretion of cytokines in
lipopolysaccharide (LPS)-induced macrophages. We discovered that studied cannabis extracts
significantly reduced the levels of cytokines, such as IL-1β, TNF-α, IL-6, IL-8, MCP-1, and
IL-10, while not being cytotoxic to macrophages. This study may serve as a roadmap for the
future analysis of the anti-inflammatory effects of medical cannabis in vivo.
Description
Keywords
immunomodulators , macrophages , cytokines , Cannabis sativa extracts , anti-inflammatory agents , inflammatory disorder treatments , Anti-inflammatory agents -- Research , Cannabis -- Therapeutic use -- Research , Plant extracts -- Therapeutic use -- Research , Botany, Medical , Medicinal plants -- Research , Materia medica, Vegetable , Cannabinoids -- Therapeutic use -- Research , Terpines -- Therapeutic use -- Research , Cytokines -- Research , Macrophages -- Research , Biological response modifiers , Immune response -- Regulation , Dissertations, Academic