The effects of Cannabis sativa extracts on human macrophages in vitro

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dc.contributor.authorZaiachuk, Mariia
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorKovalchuk, Igor
dc.contributor.supervisorKovalchuk, Olga
dc.date.accessioned2021-10-28T15:56:55Z
dc.date.available2021-10-28T15:56:55Z
dc.date.issued2021
dc.degree.levelMastersen_US
dc.description.abstractInflammation is the immune system’s response to an injury due to any agent. Currently, there is a wide array of anti-inflammatory agents available; however, they cause numerous side effects which compromise patients’ quality of life. Therefore, new antiinflammatory agents and strategies are required. Multiple research articles have demonstrated the strong potential of Cannabis sativa extracts and their active ingredients, including cannabinoids and terpenes, to be used in the treatment of inflammatory disorders. The current study explores the immunomodulatory potential of cannabis extracts in vitro. We investigated how the extracts of selected novel cannabis cultivars influence the secretion of cytokines in lipopolysaccharide (LPS)-induced macrophages. We discovered that studied cannabis extracts significantly reduced the levels of cytokines, such as IL-1β, TNF-α, IL-6, IL-8, MCP-1, and IL-10, while not being cytotoxic to macrophages. This study may serve as a roadmap for the future analysis of the anti-inflammatory effects of medical cannabis in vivo.en_US
dc.identifier.urihttps://hdl.handle.net/10133/6081
dc.language.isoen_USen_US
dc.proquest.subject0982en_US
dc.proquest.subject0307en_US
dc.proquest.subject0308en_US
dc.proquestyesYesen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciencesen_US
dc.publisher.departmentDepartment of Biological Sciencesen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectimmunomodulatorsen_US
dc.subjectmacrophagesen_US
dc.subjectcytokinesen_US
dc.subjectCannabis sativa extractsen_US
dc.subjectanti-inflammatory agentsen_US
dc.subjectinflammatory disorder treatmentsen_US
dc.subjectAnti-inflammatory agents -- Researchen_US
dc.subjectCannabis -- Therapeutic use -- Researchen_US
dc.subjectPlant extracts -- Therapeutic use -- Researchen_US
dc.subjectBotany, Medicalen_US
dc.subjectMedicinal plants -- Researchen_US
dc.subjectMateria medica, Vegetableen_US
dc.subjectCannabinoids -- Therapeutic use -- Researchen_US
dc.subjectTerpines -- Therapeutic use -- Researchen_US
dc.subjectCytokines -- Researchen_US
dc.subjectMacrophages -- Researchen_US
dc.subjectBiological response modifiersen_US
dc.subjectImmune response -- Regulationen_US
dc.subjectDissertations, Academicen_US
dc.titleThe effects of Cannabis sativa extracts on human macrophages in vitroen_US
dc.typeThesisen_US
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