Multidimensional early postnatal stress permanently programs metabolism, development, and behaviour: linking trauma to adverse health outcomes

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dc.contributor.authorPoplawski, Janet
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorMetz, Gerlinde A. S.
dc.contributor.supervisorMontina, Tony
dc.date.accessioned2019-09-06T16:35:32Z
dc.date.available2019-09-06T16:35:32Z
dc.date.issued2019
dc.degree.levelMastersen_US
dc.description.abstractStress is one of the most critical determinants of lifetime health. To gain insight into the underlying gene-environment interactions governing the effects of stress on development and behaviour, we (i) utilized proton nuclear magnetic spectroscopy to analyze cardiorenal and cerebral metabolomes of animals exposed to a multidimensional early-life stressor, and (ii) used immunohistochemical, transcriptomic, and behavioural analyses to examine the impacts of multidimensional early-life stress on offspring anxiety-like behaviours and visual development. Metabolomic profiles revealed significant changes as a result of early postnatal stress. Dysregulation of energy and protein metabolism suggests an increased risk of metabolic diseases like insulin resistance, cardiorenal syndrome, diabetes, obesity, and mental health disorders. Additionally, multidimensional early-life stress accelerated the functional and cellular development of the visual system. These findings provide novel insights into the effects of early-life stress on metabolism, development, and behaviour by combining behavioural, histological, metabolomic, and transcriptomic approaches in a rodent model.en_US
dc.identifier.urihttps://hdl.handle.net/10133/5552
dc.language.isoen_USen_US
dc.proquest.subject0758en_US
dc.proquest.subject0317en_US
dc.proquest.subject0423en_US
dc.proquestyesYesen_US
dc.publisherLethbridge, Alta. : Universtiy of Lethbridge, Department of Neuroscienceen_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectadverse healthen_US
dc.subjectdevelopmental neuroscienceen_US
dc.subjectearly postnatal stressen_US
dc.subjectmetabolomicsen_US
dc.subjecttraumaen_US
dc.subjectDissertations, Academicen_US
dc.titleMultidimensional early postnatal stress permanently programs metabolism, development, and behaviour: linking trauma to adverse health outcomesen_US
dc.typeThesisen_US
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