Multidimensional early postnatal stress permanently programs metabolism, development, and behaviour: linking trauma to adverse health outcomes
University of Lethbridge. Faculty of Arts and Science
Lethbridge, Alta. : Universtiy of Lethbridge, Department of Neuroscience
Stress is one of the most critical determinants of lifetime health. To gain insight into the underlying gene-environment interactions governing the effects of stress on development and behaviour, we (i) utilized proton nuclear magnetic spectroscopy to analyze cardiorenal and cerebral metabolomes of animals exposed to a multidimensional early-life stressor, and (ii) used immunohistochemical, transcriptomic, and behavioural analyses to examine the impacts of multidimensional early-life stress on offspring anxiety-like behaviours and visual development. Metabolomic profiles revealed significant changes as a result of early postnatal stress. Dysregulation of energy and protein metabolism suggests an increased risk of metabolic diseases like insulin resistance, cardiorenal syndrome, diabetes, obesity, and mental health disorders. Additionally, multidimensional early-life stress accelerated the functional and cellular development of the visual system. These findings provide novel insights into the effects of early-life stress on metabolism, development, and behaviour by combining behavioural, histological, metabolomic, and transcriptomic approaches in a rodent model.
adverse health , developmental neuroscience , early postnatal stress , metabolomics , trauma , Dissertations, Academic