A day in the life of Mus musculus: homecage behavioural analysis of a mouse model of Alzheimer disease

Abstract

Traditionally, behavioural research of Alzheimer disease animal models involved specialized experiments that require dedicated apparatus and presence of experimenter. However, experiment apparatus and the interaction between animals and experimenters can influence the behaviours of the animals, and result in difficulty in reproducibility. One recent innovation is to study behaviours of Alzheimer disease mouse model in their homecages. This thesis presents an experiment using automated homecages to observe the homecage behaviours of 5xFAD mouse models over 26 weeks. By measuring daily activity level, circadian rhythm and excursion behaviours, the experiment successfully produces measurements consistent with prior knowledge and provides some further insight in the behaviours of the mouse model. This thesis validates the approach using homecage behaviours as a paradigm for AD animal research.