A day in the life of Mus musculus: homecage behavioural analysis of a mouse model of Alzheimer disease

Simple item page
dc.contributor.authorLiang, Jiajie
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorMohajerani, Majid H.
dc.contributor.supervisorCheng, Howard
dc.date.accessioned2024-04-08T19:26:34Z
dc.date.available2024-04-08T19:26:34Z
dc.date.issued2023
dc.degree.levelMasters
dc.description.abstractTraditionally, behavioural research of Alzheimer disease animal models involved specialized experiments that require dedicated apparatus and presence of experimenter. However, experiment apparatus and the interaction between animals and experimenters can influence the behaviours of the animals, and result in difficulty in reproducibility. One recent innovation is to study behaviours of Alzheimer disease mouse model in their homecages. This thesis presents an experiment using automated homecages to observe the homecage behaviours of 5xFAD mouse models over 26 weeks. By measuring daily activity level, circadian rhythm and excursion behaviours, the experiment successfully produces measurements consistent with prior knowledge and provides some further insight in the behaviours of the mouse model. This thesis validates the approach using homecage behaviours as a paradigm for AD animal research.
dc.embargoNo
dc.identifier.urihttps://hdl.handle.net/10133/6730
dc.language.isoen
dc.proquest.subject0317
dc.proquestyesYes
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience
dc.publisher.departmentDepartment of Neuroscience
dc.publisher.facultyArts and Science
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)
dc.subjectAlzheimer disease
dc.subjecthomecage
dc.subject5xFAD
dc.subjectbehaviours
dc.subjectmouse
dc.subject.lcshAlzheimer's disease--Animal models--Research
dc.subject.lcshMice as laboratory animals
dc.subject.lcshLaboratory animals--Housing
dc.subject.lcshTransgenic mice--Housing
dc.subject.lcshBehavioral assessment--Animal models
dc.subject.lcshDissertations, Academic
dc.titleA day in the life of Mus musculus: homecage behavioural analysis of a mouse model of Alzheimer disease
dc.typeThesis
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
LIANG_JIAJIE_MSC_2024.pdf
Size:
3.33 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
3.25 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Arts and Science, Faculty of
University of Lethbridge Theses