Hippocampal overshadowing : exploring the underlying mechanisms

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dc.contributor.authorGulbrandsen, Tine L
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorSutherland, Robert J.
dc.date.accessioned2015-09-28T16:47:28Z
dc.date.available2015-09-28T16:47:28Z
dc.date.issued2015
dc.degree.levelPh.Den_US
dc.description.abstractThe aim of the current thesis was to evaluate the underlying mechanisms of hippocampal (HPC) overshadowing. One theory to explain this phenomenon predicts that perceptual representation of an event is stored in non-HPC cortical areas. Following multiple distributed exposure to the same or similar event, this representation becomes stable and the cellular activation patterns can be recalled in the absence of HPC input. Through a series of experiments, the hypothesis that the dysgraunlar layer of the retrosplenial cortex (RSD) fulfill these requirements was tested. Using double in-situ hybridization for the mRNA of immediate-early genes Arc and Homer1a, the cellular activation patterns in HPC subregion CA1 and RSD were evaluated. In addition, temporary inactivation of HPC was used to evaluate cellular activation patterns of a HPC-independent memory in RSD. The results presented here support the idea that cellular activation patterns for may be stored – at least in part – in the RSD.en_US
dc.embargoNoen_US
dc.identifier.urihttps://hdl.handle.net/10133/3750
dc.language.isoen_CAen_US
dc.proquest.subject0317en_US
dc.proquestyesYesen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Neuroscienceen_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjecthippocampusen_US
dc.subjectlearningen_US
dc.subjectmemoryen_US
dc.subjectovershadowingen_US
dc.titleHippocampal overshadowing : exploring the underlying mechanismsen_US
dc.typeThesisen_US
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