The effects of cannabinoid compounds on the brain and behaviour of mouse models of Alzheimer's disease

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Nixon, Abigail G.
University of Lethbridge.Faculty of Arts and Science
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Lethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience
Compounds derived from the plant Cannabis demonstrate many therapeutic properties suggesting that they could delay the onset and progression of Alzheimer’s disease (AD). The goal of the present experiment was to observe the effects of various dosages of cannabidiol (CBD) and Δ9-Tetrahydrocannabinol (THC) on the behaviour and brain pathology of an AD mouse model that expresses amyloid-beta (Aβ), APPNL-G-F mice. Additionally, we assessed the effects of 20mg/kg of CBD on the behaviour and brain pathology of a tauopathy mouse model, Tau P301S mice. Overall, various dosages of CBD and THC did not impact the behaviour or accumulation of Aβ and inflammation amongst APPNL-G-F mice. There was a dose dependent trend towards CBD, but not THC increasing the hippocampus (HPC) volume of APPNL-G-F mice. Similarly, CBD did not impact the behaviour or inflammation amongst Tau P301S mice. Finally, CBD did not restore neurodegeneration in the HPC of the Tau P301S mice.
Alzheimer's disease , Inflammation , Pathology , Learning and memory , Cannabidiol , Tetrahydrocannabinol , Mouse models