The effects of cannabinoid compounds on the brain and behaviour of mouse models of Alzheimer's disease

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dc.contributor.authorNixon, Abigail G.
dc.contributor.authorUniversity of Lethbridge.Faculty of Arts and Science
dc.contributor.supervisorMcDonald, Robert J.
dc.date.accessioned2022-07-29T19:41:27Z
dc.date.available2022-07-29T19:41:27Z
dc.date.issued2022
dc.degree.levelMastersen_US
dc.description.abstractCompounds derived from the plant Cannabis demonstrate many therapeutic properties suggesting that they could delay the onset and progression of Alzheimer’s disease (AD). The goal of the present experiment was to observe the effects of various dosages of cannabidiol (CBD) and Δ9-Tetrahydrocannabinol (THC) on the behaviour and brain pathology of an AD mouse model that expresses amyloid-beta (Aβ), APPNL-G-F mice. Additionally, we assessed the effects of 20mg/kg of CBD on the behaviour and brain pathology of a tauopathy mouse model, Tau P301S mice. Overall, various dosages of CBD and THC did not impact the behaviour or accumulation of Aβ and inflammation amongst APPNL-G-F mice. There was a dose dependent trend towards CBD, but not THC increasing the hippocampus (HPC) volume of APPNL-G-F mice. Similarly, CBD did not impact the behaviour or inflammation amongst Tau P301S mice. Finally, CBD did not restore neurodegeneration in the HPC of the Tau P301S mice.en_US
dc.description.sponsorshipULRF (2020) CIHR (2021)en_US
dc.identifier.urihttps://hdl.handle.net/10133/6299
dc.language.isoen_USen_US
dc.proquest.subject0317en_US
dc.proquestyesYesen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Neuroscienceen_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectAlzheimer's diseaseen_US
dc.subjectInflammationen_US
dc.subjectPathologyen_US
dc.subjectLearning and memoryen_US
dc.subjectCannabidiolen_US
dc.subjectTetrahydrocannabinolen_US
dc.subjectMouse modelsen_US
dc.subject.lcshCannabinoids--Therapeutic use
dc.subject.lcshCannabinoids--Research
dc.subject.lcshAlzheimer's disease--Research
dc.subject.lcshDissertations, Academic
dc.titleThe effects of cannabinoid compounds on the brain and behaviour of mouse models of Alzheimer's diseaseen_US
dc.typeThesisen_US
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