Structural alterations in the hippocampus and spatial behavior by stress in male and female rats : protections, and recovery in water-based and dry-land tasks
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Date
2008
Authors
Faraji, Jamshid
University of Lethbridge. Faculty of Arts and Science
Journal Title
Journal ISSN
Volume Title
Publisher
Lethbridge, Alta : University of Lethbridge, Faculty of Arts and Science, 2008
Abstract
Stress-related cognitive changes are still a matter of debate. In some
particular neuropathological conditions such as focal ischemia, cognitive
functions have been shown to be significantly impaired. These conditions,
however, may be improved by some factors such as steroid hormones. The
purpose of the current thesis was to assess the structural and functional effects
of corticosterone-related experiences on the hippocampus before and after
endothelin-1 (ET-1)-induced stroke. We found corticosterone-related experiences
enhance the hippocampal recovery, and improve its function in both wet and dryland
tasks after ET-1-induced focal stroke. Structural and functional effects of
such experiences prior to the focal ischemia in the hippocampus, however,
showed that stress, not corticosterone is a strong inhibitor for hippocampal
recovery.
Description
xii, 252 leaves : ill. ; 29 cm. --
Keywords
Dissertations, Academic , Cerebrovascular disease -- Research , Cerebrovascular disease -- Animal models , Spatial behavior in animals -- Research , Brain -- Research , Hippocampus (Brain) -- Physiology , Rats as laboratory animals , Stress (Physiology) -- Research , Rats -- Effect of stress on