Structural alterations in the hippocampus and spatial behavior by stress in male and female rats : protections, and recovery in water-based and dry-land tasks

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dc.contributor.authorFaraji, Jamshid
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorSutherland, Robert J.
dc.contributor.supervisorMetz, Gerlinde A. S.
dc.date.accessioned2009-07-07T20:50:44Z
dc.date.available2009-07-07T20:50:44Z
dc.date.issued2008
dc.degree.disciplineNeuroscience
dc.degree.fieldArts and Science
dc.degree.levelDoctor of Philosophy
dc.degree.subfieldSciences
dc.descriptionxii, 252 leaves : ill. ; 29 cm. --en
dc.description.abstractStress-related cognitive changes are still a matter of debate. In some particular neuropathological conditions such as focal ischemia, cognitive functions have been shown to be significantly impaired. These conditions, however, may be improved by some factors such as steroid hormones. The purpose of the current thesis was to assess the structural and functional effects of corticosterone-related experiences on the hippocampus before and after endothelin-1 (ET-1)-induced stroke. We found corticosterone-related experiences enhance the hippocampal recovery, and improve its function in both wet and dryland tasks after ET-1-induced focal stroke. Structural and functional effects of such experiences prior to the focal ischemia in the hippocampus, however, showed that stress, not corticosterone is a strong inhibitor for hippocampal recovery.en
dc.identifier.urihttps://hdl.handle.net/10133/725
dc.language.isoen_USen
dc.librarysymbolALU
dc.organizationUniversity of Lethbridge
dc.organizationUniversity of Lethbridge
dc.publisherLethbridge, Alta : University of Lethbridge, Faculty of Arts and Science, 2008en
dc.publisher.departmentNeuroscienceen
dc.publisher.facultyArts and Scienceen
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en
dc.subjectDissertations, Academicen
dc.subjectCerebrovascular disease -- Researchen
dc.subjectCerebrovascular disease -- Animal modelsen
dc.subjectSpatial behavior in animals -- Researchen
dc.subjectBrain -- Researchen
dc.subjectHippocampus (Brain) -- Physiologyen
dc.subjectRats as laboratory animalsen
dc.subjectStress (Physiology) -- Researchen
dc.subjectRats -- Effect of stress onen
dc.titleStructural alterations in the hippocampus and spatial behavior by stress in male and female rats : protections, and recovery in water-based and dry-land tasksen
dc.typeThesisen
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