Consequences of maternal preconception nicotine and alcohol: a rodent model of the long-term effects on offspring brain and behavior

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Jenkins, Serena
University of Lethbridge. Faculty of Arts and Science
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Lethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience
This thesis explores the impacts of maternal preconception experience on the development of brain and behavior in the next generation. Chapter 1 provides a review of the literature on prenatal and preconception exposure to common recreational drugs of abuse, nicotine and alcohol. The review covers behavioral, neuroanatomical, molecular/epigenetic, and physiological impacts of developmental drug exposure. Chapter 2 discusses the results of an experiment that investigated the early impacts of maternal preconception nicotine and environmental enrichment. Chapter 3 covers how maternal preconception nicotine and enrichment continue to affect development in adolescent and adult offspring. Chapter 4 discusses an experiment into the impacts of maternal preconception alcoholism on offspring development throughout life. Chapter 5 presents a brief general conclusion. The overall goal of this thesis is to highlight how maternal experiences prior to conception can have just as significant an impact on offspring development as much more thoroughly studied prenatal experiences.
Behavioral Neuroscience , Alcohol , Alcohol -- Physiological effect , Animals -- Drug use , Dissertations, Academic , Nicotine , Nicotine -- Physiological effect , Preconception care