Consequences of maternal preconception nicotine and alcohol: a rodent model of the long-term effects on offspring brain and behavior

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dc.contributor.authorJenkins, Serena
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorGibb, Robbin L.
dc.date.accessioned2021-09-23T15:46:44Z
dc.date.available2021-09-23T15:46:44Z
dc.date.issued2021
dc.degree.levelPh.Den_US
dc.description.abstractThis thesis explores the impacts of maternal preconception experience on the development of brain and behavior in the next generation. Chapter 1 provides a review of the literature on prenatal and preconception exposure to common recreational drugs of abuse, nicotine and alcohol. The review covers behavioral, neuroanatomical, molecular/epigenetic, and physiological impacts of developmental drug exposure. Chapter 2 discusses the results of an experiment that investigated the early impacts of maternal preconception nicotine and environmental enrichment. Chapter 3 covers how maternal preconception nicotine and enrichment continue to affect development in adolescent and adult offspring. Chapter 4 discusses an experiment into the impacts of maternal preconception alcoholism on offspring development throughout life. Chapter 5 presents a brief general conclusion. The overall goal of this thesis is to highlight how maternal experiences prior to conception can have just as significant an impact on offspring development as much more thoroughly studied prenatal experiences.en_US
dc.identifier.urihttps://hdl.handle.net/10133/6038
dc.language.isoen_USen_US
dc.proquest.subject0602en_US
dc.proquest.subjectNeurosciences [0317]en_US
dc.proquest.subjectBehavioral sciences [0602]en_US
dc.proquest.subjectAnimal sciences [0475]en_US
dc.proquestyesYesen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Neuroscienceen_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectBehavioral Neuroscienceen_US
dc.subjectAlcoholen_US
dc.subjectAlcohol -- Physiological effecten_US
dc.subjectAnimals -- Drug useen_US
dc.subjectDissertations, Academicen_US
dc.subjectNicotineen_US
dc.subjectNicotine -- Physiological effecten_US
dc.subjectPreconception careen_US
dc.titleConsequences of maternal preconception nicotine and alcohol: a rodent model of the long-term effects on offspring brain and behavioren_US
dc.typeThesisen_US
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