On the distribution of transcription times

Roussel, Marc R.

On the distribution of transcription times

dc.contributor.author	Roussel, Marc R.
dc.date.accessioned	2019-06-25T18:15:29Z
dc.date.available	2019-06-25T18:15:29Z
dc.date.issued	2013
dc.description	Open access article. Creative Commons Attribution 3.0 Unported License (CC BY 3.0) applies	en_US
dc.description.abstract	A previously studied model of prokaryotic transcription [Roussel and Zhu, Bull. Math. Biol. 68 (2006) 1681--1713] is revisited. The first four moments of the distribution of transcription times are obtained analytically and analyzed. A Gaussian is found to be a poor approximation to this distribution for short transcription units at typical values of the rate constants, but a good approximation for long transcription units. An approximate form of the distribution is obtained in which the slow steps are treated exactly and the fast steps are lumped together into a single lag term. This approximate form might be particularly useful as a function to be fit to experimental transcription time distributions. Multi-polymerase effects are also studied by simulation. We find that the analytic model generally predicts the behavior of the multi-polymerase simulations, often quantitatively, provided termination is not rate-limiting.	en_US
dc.description.peer-review	Yes	en_US
dc.identifier.citation	Roussel, M. R. (2013). On the distribution of transcription times. Biomath, 2(1), 130724, 1-14. http://dx.doi.org/10.11145/150	en_US
dc.identifier.uri	https://hdl.handle.net/10133/5430
dc.language.iso	en_US	en_US
dc.publisher	Biomath Forum	en_US
dc.publisher.department	Department of Chemistry and Biochemistry	en_US
dc.publisher.faculty	Arts and Science	en_US
dc.publisher.institution	University of Lethbridge	en_US
dc.publisher.url	http://dx.doi.org/10.11145/j.biomath.2013.07.247
dc.subject	Gene transcription	en_US
dc.subject	Stochastic model	en_US
dc.title	On the distribution of transcription times	en_US
dc.type	Article	en_US