On the distribution of transcription times

dc.contributor.authorRoussel, Marc R.
dc.date.accessioned2019-06-25T18:15:29Z
dc.date.available2019-06-25T18:15:29Z
dc.date.issued2013
dc.descriptionOpen access article. Creative Commons Attribution 3.0 Unported License (CC BY 3.0) appliesen_US
dc.description.abstractA previously studied model of prokaryotic transcription [Roussel and Zhu, Bull. Math. Biol. 68 (2006) 1681--1713] is revisited. The first four moments of the distribution of transcription times are obtained analytically and analyzed. A Gaussian is found to be a poor approximation to this distribution for short transcription units at typical values of the rate constants, but a good approximation for long transcription units. An approximate form of the distribution is obtained in which the slow steps are treated exactly and the fast steps are lumped together into a single lag term. This approximate form might be particularly useful as a function to be fit to experimental transcription time distributions. Multi-polymerase effects are also studied by simulation. We find that the analytic model generally predicts the behavior of the multi-polymerase simulations, often quantitatively, provided termination is not rate-limiting.en_US
dc.description.peer-reviewYesen_US
dc.identifier.citationRoussel, M. R. (2013). On the distribution of transcription times. Biomath, 2(1), 130724, 1-14. http://dx.doi.org/10.11145/150en_US
dc.identifier.urihttps://hdl.handle.net/10133/5430
dc.language.isoen_USen_US
dc.publisherBiomath Forumen_US
dc.publisher.departmentDepartment of Chemistry and Biochemistryen_US
dc.publisher.facultyArts and Scienceen_US
dc.publisher.institutionUniversity of Lethbridgeen_US
dc.publisher.urlhttp://dx.doi.org/10.11145/j.biomath.2013.07.247
dc.subjectGene transcriptionen_US
dc.subjectStochastic modelen_US
dc.titleOn the distribution of transcription timesen_US
dc.typeArticleen_US
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