Characterization of the effects of 2-(2H-Benzotriazol-2-yl)-4-methylphenol (UV-P) to the model fish species, Japanese medaka (Oryzias latipes)

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Fujita, Kaden
University of Lethbridge. Faculty of Arts and Science
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Lethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciences
Environmental pollution is a major contributor to declines in populations of fish. Recently, benzotriazole ultraviolet stabilizers (BZT-UVs) have emerged as pollutants of concern. Although these compounds are detected globally in aquatic ecosystems, few studies have investigated the potential toxic effects of these chemicals to fish. The objectives of this study were to assess the potential adverse effects that a BZT-UV, specifically 2-(2H-Benzotriazol-2-yl)-4-methylphenol (UV-P), has to fish. To test this, effects of UV-P on reproduction were assessed. Effects of UV-P on the liver metabolome of Japanese medaka were assessed to investigate potential mechanisms of toxicity. Exposure to UV-P did not impair reproduction in Japanese medaka, however, qPCR suggested there was altered expression of genes related to the steroidogenesis pathway. Additionally, metabolomics analysis indicated potential perturbation of various biological pathways. Overall, this study fills a knowledge gap regarding the potential effects of BZT-UVs on fish populations.
Research Subject Categories::NATURAL SCIENCES , Water -- Pollution , Water -- Pollution potential , Dissertations, Academic , Aquatic animals -- Effect of water pollution on , Oryzias latipes , Benzothiazoles -- Toxicology