Characterization of the effects of 2-(2H-Benzotriazol-2-yl)-4-methylphenol (UV-P) to the model fish species, Japanese medaka (Oryzias latipes)

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dc.contributor.authorFujita, Kaden
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorWiseman, Steve
dc.contributor.supervisorMontina, Tony
dc.date.accessioned2021-09-17T00:11:39Z
dc.date.available2021-09-17T00:11:39Z
dc.date.issued2021
dc.degree.levelMastersen_US
dc.description.abstractEnvironmental pollution is a major contributor to declines in populations of fish. Recently, benzotriazole ultraviolet stabilizers (BZT-UVs) have emerged as pollutants of concern. Although these compounds are detected globally in aquatic ecosystems, few studies have investigated the potential toxic effects of these chemicals to fish. The objectives of this study were to assess the potential adverse effects that a BZT-UV, specifically 2-(2H-Benzotriazol-2-yl)-4-methylphenol (UV-P), has to fish. To test this, effects of UV-P on reproduction were assessed. Effects of UV-P on the liver metabolome of Japanese medaka were assessed to investigate potential mechanisms of toxicity. Exposure to UV-P did not impair reproduction in Japanese medaka, however, qPCR suggested there was altered expression of genes related to the steroidogenesis pathway. Additionally, metabolomics analysis indicated potential perturbation of various biological pathways. Overall, this study fills a knowledge gap regarding the potential effects of BZT-UVs on fish populations.en_US
dc.identifier.urihttps://hdl.handle.net/10133/6030
dc.language.isoen_USen_US
dc.proquest.subjectEnvironmental Science [0768]en_US
dc.proquest.subjectEcology [0329]en_US
dc.proquest.subjectAquatic sciences [0792]en_US
dc.proquestyesNoen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciencesen_US
dc.publisher.departmentDepartment of Biological Sciencesen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectResearch Subject Categories::NATURAL SCIENCESen_US
dc.subjectWater -- Pollutionen_US
dc.subjectWater -- Pollution potentialen_US
dc.subjectDissertations, Academicen_US
dc.subjectAquatic animals -- Effect of water pollution onen_US
dc.subjectOryzias latipesen_US
dc.subjectBenzothiazoles -- Toxicologyen_US
dc.titleCharacterization of the effects of 2-(2H-Benzotriazol-2-yl)-4-methylphenol (UV-P) to the model fish species, Japanese medaka (Oryzias latipes)en_US
dc.typeThesisen_US
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