Pre-clinical trials: the impact of tactile stimulation on the development of Alzheimer's Disease pathology in APP mice.

Abstract

Alzheimer’s Disease (AD) is a one of the largest health crises in the world. Noise stress is identified as one of the risk factors for AD development. A series of research demonstrates the adverse of effects of both pre- and post-natal auditory/noise stress on the brain development in adult offspring and adults APPNL-G-F mice, a mouse model of AD. There are limited but expensive pharmaceutical interventions to treat AD and most of the treatment options are not for cure or prevention, but to slow down the progression of the disease. The aim of this thesis was to examine the effect of tactile stimulation (TS) on AD-like symptoms and pathology. The results from this study suggest that TS improves the AD-like symptoms of cognition, motor, and anxiety-like behaviours, and that these improvements are associated with reduced AD pathology in APP mice.