Pre-clinical trials: the impact of tactile stimulation on the development of Alzheimer's Disease pathology in APP mice.

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dc.contributor.authorHossain, Shakhawat
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorKolb, Bryan
dc.contributor.supervisorMohajerani, Majid H.
dc.date.accessioned2020-01-17T19:09:47Z
dc.date.available2020-01-17T19:09:47Z
dc.date.issued2019
dc.degree.levelMastersen_US
dc.description.abstractAlzheimer’s Disease (AD) is a one of the largest health crises in the world. Noise stress is identified as one of the risk factors for AD development. A series of research demonstrates the adverse of effects of both pre- and post-natal auditory/noise stress on the brain development in adult offspring and adults APPNL-G-F mice, a mouse model of AD. There are limited but expensive pharmaceutical interventions to treat AD and most of the treatment options are not for cure or prevention, but to slow down the progression of the disease. The aim of this thesis was to examine the effect of tactile stimulation (TS) on AD-like symptoms and pathology. The results from this study suggest that TS improves the AD-like symptoms of cognition, motor, and anxiety-like behaviours, and that these improvements are associated with reduced AD pathology in APP mice.en_US
dc.description.sponsorshipARNET, NSERCen_US
dc.identifier.urihttps://hdl.handle.net/10133/5667
dc.language.isoen_USen_US
dc.proquest.subjectNeurosciences [0317en_US
dc.proquest.subjectMental health [0347]en_US
dc.proquest.subjectMedicine [0564]en_US
dc.proquestyesYesen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Neuroscienceen_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectAlzheimer’s diseaseen_US
dc.subjectNeuroplasticityen_US
dc.subjectNoise pollutionen_US
dc.subjectStress (Physiology)en_US
dc.titlePre-clinical trials: the impact of tactile stimulation on the development of Alzheimer's Disease pathology in APP mice.en_US
dc.typeThesisen_US
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