Adrenalectomy-induced neuronal degeneration : development of a novel animal model of cognitive dysfuntion and neurogenic treatment strategies

Thumbnail Image
Spanswick, Simon C.
University of Lethbridge. Faculty of Arts and Science
Journal Title
Journal ISSN
Volume Title
Lethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience, 2010
Long-term adrenalectomy (ADX) results in a specific loss of dentate gyrus granule cells in the hippocampus of adult rats, occurring over a period of weeks to months. This loss of granule cells results in cognitive deficits in a number of tasks that depend on intact hippocampal function. The gradual nature of ADX-induced cell death and the ensuing deficits in cognition are similar to those experienced by patient populations suffering from a variety of pathological conditions. Here we present an animal model by which we use ADX to produce a loss of granule cells within the hippocampus of rats. We also provide experimental evidence for a treatment strategy by which the lost granule cells may be replaced, with the goal of functional recovery in mind.
xii, 191 leaves : ill. (chiefly col.) ; 28 cm
Dentate gyrus -- Research , Hippocampus (Brain) -- Research , Adrenalectomy , Developmental neurobiology , Brain -- Research , Rats as laboratory animals , Neuroplasticity -- Research , Dissertations, Academic