Adrenalectomy-induced neuronal degeneration : development of a novel animal model of cognitive dysfuntion and neurogenic treatment strategies

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dc.contributor.authorSpanswick, Simon C.
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorSutherland, Robert J.
dc.date.accessioned2011-12-22T22:28:09Z
dc.date.available2011-12-22T22:28:09Z
dc.date.issued2010
dc.degree.disciplineNeuroscience
dc.degree.fieldArts and Sciences
dc.degree.levelDoctor of Philosophy
dc.degree.levelPhD
dc.descriptionxii, 191 leaves : ill. (chiefly col.) ; 28 cmen_US
dc.description.abstractLong-term adrenalectomy (ADX) results in a specific loss of dentate gyrus granule cells in the hippocampus of adult rats, occurring over a period of weeks to months. This loss of granule cells results in cognitive deficits in a number of tasks that depend on intact hippocampal function. The gradual nature of ADX-induced cell death and the ensuing deficits in cognition are similar to those experienced by patient populations suffering from a variety of pathological conditions. Here we present an animal model by which we use ADX to produce a loss of granule cells within the hippocampus of rats. We also provide experimental evidence for a treatment strategy by which the lost granule cells may be replaced, with the goal of functional recovery in mind.en_US
dc.identifier.urihttps://hdl.handle.net/10133/2587
dc.language.isoen_USen_US
dc.librarysymbolALU
dc.organizationUniversity of Lethbridge
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience, 2010en_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectDentate gyrus -- Researchen_US
dc.subjectHippocampus (Brain) -- Researchen_US
dc.subjectAdrenalectomyen_US
dc.subjectDevelopmental neurobiologyen_US
dc.subjectBrain -- Researchen_US
dc.subjectRats as laboratory animalsen_US
dc.subjectNeuroplasticity -- Researchen_US
dc.subjectDissertations, Academicen_US
dc.titleAdrenalectomy-induced neuronal degeneration : development of a novel animal model of cognitive dysfuntion and neurogenic treatment strategiesen_US
dc.typeThesisen_US
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