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dc.contributor.supervisor Sutherland, Robert J.
dc.contributor.author Melvin, Neal
dc.contributor.author University of Lethbridge. Faculty of Arts and Science
dc.date.accessioned 2009-07-07T20:51:40Z
dc.date.available 2009-07-07T20:51:40Z
dc.date.issued 2008
dc.identifier.uri https://hdl.handle.net/10133/727
dc.description xvi, 125 leaves : ill. ; 29 cm. -- en
dc.description.abstract Adult neurogenesis is a fundamental feature of mammalian nervous systems. Curiously, neurogenesis in the dentate gyrus is typically regarded as homogenous. This thesis challenges that view, and reports the discovery and characterization of a novel region of the dentate gyrus that consistently lacks basal neurogenesis. We demonstrate that this area, referred to as the neurogenically quiescent zone, represents approximately 1.5% of the total volume of the dentate gyrus, and that its location is invariant among animals. This region contains several critical cell types and molecular factors that are known to be critical to the neurogenic niche, including stem cells. We also present data that attempt to conceptualize the existence of this region in the context of early agerelated declines in neurogenesis. Finally, we demonstrate that, under some behavioural conditions, neurogenesis can be induced in this region, suggesting that, under basal conditions, it may simply lack the presence of pro-neurogenic factors. en
dc.language.iso en_US en
dc.publisher Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2008 en
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en
dc.subject Dissertations, Academic en
dc.subject Developmental neurobiology en
dc.subject Dentate gyrus en
dc.subject Brain -- Research en
dc.subject Rats as laboratory animals en
dc.subject Hippocampus (Brain) en
dc.title Differential neurogenesis in the adult rat dentate gyrus en
dc.type Thesis en
dc.publisher.faculty Arts and Science en
dc.publisher.department Neuroscience en
dc.degree.level Doctor of Philosophy
dc.degree.discipline Neuroscience
dc.organization University of Lethbridge
dc.librarysymbol ALU
dc.degree.field Arts and Science
dc.degree.subfield Sciences


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