Differential neurogenesis in the adult rat dentate gyrus

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dc.contributor.authorMelvin, Neal
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorSutherland, Robert J.
dc.date.accessioned2009-07-07T20:51:40Z
dc.date.available2009-07-07T20:51:40Z
dc.date.issued2008
dc.degree.disciplineNeuroscience
dc.degree.fieldArts and Science
dc.degree.levelDoctor of Philosophy
dc.degree.subfieldSciences
dc.descriptionxvi, 125 leaves : ill. ; 29 cm. --en
dc.description.abstractAdult neurogenesis is a fundamental feature of mammalian nervous systems. Curiously, neurogenesis in the dentate gyrus is typically regarded as homogenous. This thesis challenges that view, and reports the discovery and characterization of a novel region of the dentate gyrus that consistently lacks basal neurogenesis. We demonstrate that this area, referred to as the neurogenically quiescent zone, represents approximately 1.5% of the total volume of the dentate gyrus, and that its location is invariant among animals. This region contains several critical cell types and molecular factors that are known to be critical to the neurogenic niche, including stem cells. We also present data that attempt to conceptualize the existence of this region in the context of early agerelated declines in neurogenesis. Finally, we demonstrate that, under some behavioural conditions, neurogenesis can be induced in this region, suggesting that, under basal conditions, it may simply lack the presence of pro-neurogenic factors.en
dc.identifier.urihttps://hdl.handle.net/10133/727
dc.language.isoen_USen
dc.librarysymbolALU
dc.organizationUniversity of Lethbridge
dc.publisherLethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2008en
dc.publisher.departmentNeuroscienceen
dc.publisher.facultyArts and Scienceen
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en
dc.subjectDissertations, Academicen
dc.subjectDevelopmental neurobiologyen
dc.subjectDentate gyrusen
dc.subjectBrain -- Researchen
dc.subjectRats as laboratory animalsen
dc.subjectHippocampus (Brain)en
dc.titleDifferential neurogenesis in the adult rat dentate gyrusen
dc.typeThesisen
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