Show simple item record

dc.contributor.supervisor Prusky, Glen
dc.contributor.author McGill, Trevor
dc.contributor.author University of Lethbridge. Faculty of Arts and Science
dc.date.accessioned 2009-07-07T20:51:15Z
dc.date.available 2009-07-07T20:51:15Z
dc.date.issued 2008
dc.identifier.uri https://hdl.handle.net/10133/726
dc.description xvii, 205 leaves : ill. ; 29 cm. -- en
dc.description.abstract The established model used for evaluating potential therapies for retinal disease has significant limitations. A new model is proposed to account for these limitations: the visual adaptation model. The visual adaptation model was developed to provide a novel approach for testing potential treatments for retinal disease, and the work in this thesis provides empirical support for this model. Specifically, we evaluated two potential therapies for retinal degenerative disease and examined their effects on vision and retinal anatomy. In addition, the profile of retinal reorganization and its functional correlates were examined in RCS rats and transgenic rats which express a rhodopsin mutation; however, immunohistological work targeted one specific line (S334ter-4). Collectively, these studies provide evidence that supports the retinal adaptation model. These studies also provide a novel view of retinal and visual function in retinal disease which should be considered when evaluating treatments involving retinal degeneration. en
dc.language.iso en_US en
dc.publisher Lethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2008 en
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en
dc.subject Dissertations, Academic en
dc.subject Retina -- Diseases -- Research en
dc.subject Retinal degeneration -- Research en
dc.subject Retinitis pigmentosa -- Research en
dc.title Functionally non-adaptive retinal plasticity in rat models of human retinal degenerative disease en
dc.type Thesis en
dc.publisher.faculty Arts and Science en
dc.publisher.department Neuroscience en
dc.degree.level Doctor of Philosophy
dc.degree.discipline Neuroscience
dc.organization University of Lethbridge
dc.librarysymbol ALU
dc.degree.field Arts and Science
dc.degree.subfield Sciences


Files in this item

This item appears in the following Collection(s)

Show simple item record