Functionally non-adaptive retinal plasticity in rat models of human retinal degenerative disease

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dc.contributor.authorMcGill, Trevor
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorPrusky, Glen
dc.date.accessioned2009-07-07T20:51:15Z
dc.date.available2009-07-07T20:51:15Z
dc.date.issued2008
dc.degree.disciplineNeuroscience
dc.degree.fieldArts and Science
dc.degree.levelDoctor of Philosophy
dc.degree.subfieldSciences
dc.descriptionxvii, 205 leaves : ill. ; 29 cm. --en
dc.description.abstractThe established model used for evaluating potential therapies for retinal disease has significant limitations. A new model is proposed to account for these limitations: the visual adaptation model. The visual adaptation model was developed to provide a novel approach for testing potential treatments for retinal disease, and the work in this thesis provides empirical support for this model. Specifically, we evaluated two potential therapies for retinal degenerative disease and examined their effects on vision and retinal anatomy. In addition, the profile of retinal reorganization and its functional correlates were examined in RCS rats and transgenic rats which express a rhodopsin mutation; however, immunohistological work targeted one specific line (S334ter-4). Collectively, these studies provide evidence that supports the retinal adaptation model. These studies also provide a novel view of retinal and visual function in retinal disease which should be considered when evaluating treatments involving retinal degeneration.en
dc.identifier.urihttps://hdl.handle.net/10133/726
dc.language.isoen_USen
dc.librarysymbolALU
dc.organizationUniversity of Lethbridge
dc.publisherLethbridge, Alta. : University of Lethbridge, Faculty of Arts and Science, 2008en
dc.publisher.departmentNeuroscienceen
dc.publisher.facultyArts and Scienceen
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en
dc.subjectDissertations, Academicen
dc.subjectRetina -- Diseases -- Researchen
dc.subjectRetinal degeneration -- Researchen
dc.subjectRetinitis pigmentosa -- Researchen
dc.titleFunctionally non-adaptive retinal plasticity in rat models of human retinal degenerative diseaseen
dc.typeThesisen
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