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dc.contributor.supervisor Kovalchuk, Olga
dc.contributor.author Sagoe-Wagner, Araba
dc.contributor.author University of Lethbridge. Faculty of Arts and Science
dc.date.accessioned 2020-05-08T17:24:12Z
dc.date.available 2020-05-08T17:24:12Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/10133/5718
dc.description.abstract Emerging studies into long non-coding RNAs in cancers continue to implicate these molecules in roles crucial to tumourigenesis and progression of cancers. Long non-coding RNAs are transcripts greater than 200bp that do not code for protein but have been found to regulate gene expression. Given the extensive knowledge of mutations in the genome that could account for pediatric cancers in children, there is a need for a greater understanding of epigenetic regulation and the epigenome of osteosarcoma and neuroblastoma. LncRNAs contribute to epigenetics, thus these transcripts could also influence the cancers via epigenetic mechanisms. This thesis therefore aims to identify differentially expressed long non-coding RNA in neuroblastoma and osteosarcoma that may have roles which could serve as potential targets in therapeutics. Our findings reveal long non-coding RNAs LINC00261, LINC01133, LINC01268 and LINC01139 that are differentially expressed and could have potential roles in the progression of the disease. en_US
dc.language.iso en_US en_US
dc.publisher Lethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciences en_US
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en_US
dc.subject Cancer en_US
dc.subject Epigenetics and human health en_US
dc.subject Neuroblastoma en_US
dc.subject Non-coding RNA en_US
dc.subject Osteosarcoma in children en_US
dc.subject Tumors in children en_US
dc.title The role of long non-coding RNAs in pediatric cancers: neuroblastoma and osteosarcoma en_US
dc.type Thesis en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Biological Sciences en_US
dc.degree.level Masters en_US
dc.proquest.subject Molecular biology [0307] en_US
dc.proquest.subject Genetics [0369] en_US
dc.proquest.subject Cellular biology [0379] en_US
dc.proquestyes Yes en_US


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