The role of long non-coding RNAs in pediatric cancers: neuroblastoma and osteosarcoma

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dc.contributor.authorSagoe-Wagner, Araba
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorKovalchuk, Olga
dc.date.accessioned2020-05-08T17:24:12Z
dc.date.available2020-05-08T17:24:12Z
dc.date.issued2020
dc.degree.levelMastersen_US
dc.description.abstractEmerging studies into long non-coding RNAs in cancers continue to implicate these molecules in roles crucial to tumourigenesis and progression of cancers. Long non-coding RNAs are transcripts greater than 200bp that do not code for protein but have been found to regulate gene expression. Given the extensive knowledge of mutations in the genome that could account for pediatric cancers in children, there is a need for a greater understanding of epigenetic regulation and the epigenome of osteosarcoma and neuroblastoma. LncRNAs contribute to epigenetics, thus these transcripts could also influence the cancers via epigenetic mechanisms. This thesis therefore aims to identify differentially expressed long non-coding RNA in neuroblastoma and osteosarcoma that may have roles which could serve as potential targets in therapeutics. Our findings reveal long non-coding RNAs LINC00261, LINC01133, LINC01268 and LINC01139 that are differentially expressed and could have potential roles in the progression of the disease.en_US
dc.identifier.urihttps://hdl.handle.net/10133/5718
dc.language.isoen_USen_US
dc.proquest.subjectMolecular biology [0307]en_US
dc.proquest.subjectGenetics [0369]en_US
dc.proquest.subjectCellular biology [0379]en_US
dc.proquestyesYesen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciencesen_US
dc.publisher.departmentDepartment of Biological Sciencesen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectCanceren_US
dc.subjectEpigenetics and human healthen_US
dc.subjectNeuroblastomaen_US
dc.subjectNon-coding RNAen_US
dc.subjectOsteosarcoma in childrenen_US
dc.subjectTumors in childrenen_US
dc.titleThe role of long non-coding RNAs in pediatric cancers: neuroblastoma and osteosarcomaen_US
dc.typeThesisen_US
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