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dc.contributor.supervisor Thomas, James E.
dc.contributor.supervisor Taboada, Eduardo N.
dc.contributor.author Buchanan, Cody J.
dc.contributor.author University of Lethbridge. Faculty of Arts and Science
dc.date.accessioned 2019-05-22T21:23:37Z
dc.date.available 2019-05-22T21:23:37Z
dc.date.issued 2018
dc.identifier.uri https://hdl.handle.net/10133/5365
dc.description.abstract Despite the fact that C. jejuni is a leading cause of bacterial enteritis in Canada, there is no diagnostic assay available to identify high-risk strains. This represents a significant challenge towards the prevention and control of campylobacteriosis. Additionally, molecular epidemiological studies have shown that not all C. jejuni strains or lineages appear to pose an equal risk to human health, and the factors underlying this subtype-dependent pathogenesis are not understood. A Genome-Wide Association Study was conducted to identify genetic markers associated with C. jejuni strains linked to human illness. These markers were implemented in a molecular-based risk assessment assay, and used to screen isolates collected as part of a national microbial survey of Canadian poultry products. This study suggests that strains with a diverse metabolic toolkit may pose an elevated risk by virtue of their ability to overcome ecological barriers that might otherwise mitigate exposure to humans. en_US
dc.language.iso en_US en_US
dc.publisher Lethbridge, Alta. : Universtiy of Lethbridge, Department of Biological Sciences en_US
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en_US
dc.subject Campylobacter jejuni -- Research en_US
dc.subject Campylobacter infections -- Epidemiology en_US
dc.subject Bacterial genetics en_US
dc.subject Bacterial genomes en_US
dc.subject Pathogenic bacteria en_US
dc.subject Foodborne diseases -- Microbiology en_US
dc.subject Diagnostic bacteriology en_US
dc.subject Dissertations, Academic en_US
dc.subject diagnostic assay en_US
dc.subject gastrointestinal illness causing pathogens en_US
dc.subject high-risk strain identification en_US
dc.subject human campylobacteriosis en_US
dc.subject whole genome typing en_US
dc.title Development of a molecular-based risk assessment assay for human pathogenic Campylobacter jejuni en_US
dc.type Thesis en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Biological Sciences en_US
dc.degree.level Masters en_US
dc.proquest.subject 0306 en_US
dc.proquest.subject 0410 en_US
dc.proquest.subject 0573 en_US
dc.proquestyes Yes en_US
dc.embargo No en_US


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