Patel, Trushar

 

Recent Submissions

  • Siddiqui, M. Quadir; Badmalia, Maulik D.; Patel, Trushar R. (MDPIArts and ScienceDepartment of Chemistry and BiochemistryUniversity of LethbridgeUniversity of CalgaryUniversity of Albertahttps://doi.org/10.3390/ijms22052647, 2021)
    Members of the human Zyxin family are LIM domain-containing proteins that perform critical cellular functions and are indispensable for cellular integrity. Despite their importance, not much is known about their structure, ...
  • Meier-Stephenson, Vanessa; Badmalia, Maulik D.; Mrozowich, Tyler; Lau, Keith C. K.; Schultz, Sarah K.; Gemmill, Darren L.; Osiowy, Carla; van Marle, Guido; Coffin, Carla S.; Patel, Trushar R. (ElsevierArts and ScienceDepartment of Chemistry and BiochemistryUniversity of LethbridgeUniversity of CalgaryPublic Health Agency of CanadaUniversity of Albertahttps://doi.org/10.1016/j.jbc.2021.100589, 2021)
    Approximately 250 million people worldwide are chronically infected with the hepatitis B virus (HBV) and are at increased risk of developing cirrhosis and hepatocellular carcinoma. The HBV genome persists as covalently ...
  • Rutbeek, Nicole R.; Rezasoltani, Hanieh; Patel, Trushar R.; Khajehpour, Mazdak; Prehna, Gerd (ElsevierArts and ScienceDepartment of Chemistry and BiochemistryUniversity of ManitobaUniversity of Lethbridge, 2021)
    Streptococcus pyogenes, or Group A Streptococcus, is a Gram-positive bacterium that can be both a human commensal and a pathogen. Central to this dichotomy are temperate bacteriophages that incorporate into the bacterial ...
  • Tersteeg, Scott; Mrozowich, Tyler; Henrickson, Amy; Demeler, Borries; Patel, Trushar R. (Canadian Science PublishingArts and ScienceDepartment of Chemistry and BiochemistryUniversity of LethbridgeUniversity of AlbertaUniversity of Calgaryhttps://doi.org/10.1139/bcb-2022-0118, 2022)
    Inorganic pyrophosphatase (iPPase) is an enzyme that cleaves pyrophosphate into two phosphate molecules. This enzyme is an essential component of in vitro transcription (IVT) reactions for RNA preparation as it prevents ...
  • Nelson, Corey R.; Mrozowich, Tyler; Park, Sean M.; D'souza, Simmone; Henrickson, Amy; Vigar, Justin R. J.; Wieden, Hans-Joachim; Owens, Raymond J.; Demeler, Borries; Patel, Trushar R. (MDPIArts and ScienceDepartment of Chemistry and BiochemistryUniversity of LethbridgeUniversity of CalgaryRutherford Appleton LaboratoriesUniversity of MontanaUniversity of Albertahttps://doi.org/10.3390/ijms22010054, 2020)
    Rift Valley fever virus (RVFV) is a mosquito-transmitted virus from the Bunyaviridae family that causes high rates of mortality and morbidity in humans and ruminant animals. Previous studies indicated that DEAD-box helicase ...
  • Mrozowich, Tyler; Henrickson, Amy; Demeler, Borries; Patel, Trushar R. (MDPIArts and ScienceDepartment of Chemistry and BiochemistryUniversity of LethbridgeUniversity of MontanaUniversity of CalgaryUniversity of Albertahttps://doi.org/10.3390/v12020190, 2020)
    Viral infections are responsible for numerous deaths worldwide. Flaviviruses, which contain RNA as their genetic material, are one of the most pathogenic families of viruses. There is an increasing amount of evidence ...
  • Dzananovic, Edis; Astha; Chojnowski, Grzegorz; Deo, Soumya; Booy, Evan P.; Padilla-Meier, Pauline; McEleney, Kevin; Bujnicki, Janusz M.; Patel, Trushar R.; McKenna, Sean A. (Public Library of Sciencehttps://dx.doi.org/10.1371/journal.pone.0186849, 2017)
    Highly structured RNA derived from viral genomes is a key cellular indicator of viral infection. In response, cells produce the interferon inducible RNA-dependent protein kinase (PKR) that, when bound to viral dsRNA, ...