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dc.contributor.author Erickson, Zachary T.
dc.contributor.author Falkenberg, Erin A.
dc.contributor.author Metz, Gerlinde A. S.
dc.date.accessioned 2016-08-11T18:08:47Z
dc.date.available 2016-08-11T18:08:47Z
dc.date.issued 2014
dc.identifier.citation Erickson, Z.T., Falkenberg, E. A., & Metz, G. A. S. (2014). Lifespahn psychomotor behaviour profiles of multigenerational prenatal stress and artificial food dye effects in rats. PLoS ONE, 9(6), e92132. doi: 10.1371/journal.pone.0092132 en_US
dc.identifier.uri https://hdl.handle.net/10133/4573
dc.description Sherpa Romeo green journal, open access en_US
dc.description.abstract The consumption of artificial food dye (AFD) during childhood and adolescence has been linked to behavioural changes, such as hyperactivity. It is possible that the vulnerability to AFDs is modified by prenatal stress. Common consequences of prenatal stress include hyperactivity, thus potentially leading to synergistic actions with AFDs. Here, we investigated the compounding effect of multigenerational prenatal stress (MPS) and AFD consumption on the development of hyperactivity and anxiety-related behaviours across the lifespan in male rats. MPS treatment involved a family history of four consecutive generations of prenatal stress (F4 generation). AFD treatment included a 4%-concentration of FD&C Red 40, FD&C Yellow 5, FD&C Yellow 6, and FD&C Blue 1 in the drinking water from postnatal days 22 to 50 to resemble juvenile and adolescent dietary exposure. Using several exploration tasks, animals were tested in motor activity and anxiety-like behaviours from adolescence to 13 months of age. MPS resulted in hyperactivity both early (50 days) and later in life (13 months), with normalized activity patterns at reproductive age. AFD consumption resulted in hyperactivity during consumption, which subsided following termination of treatment. Notably, both MPS and AFD promoted risk-taking behaviour in young adults (3 months). There were few synergistic effects between MPS and AFD in this study. The findings suggest that AFDs exert the most noticeable effects at the time of exposure. MPS, however, results in a characteristic lifespan profile of behavioural changes, indicating that development and aging represent particularly vulnerable periods in life during which a family history of prenatal stress may precipitate. en_US
dc.language.iso en_CA en_US
dc.publisher Public Library of Science en_US
dc.subject Artificial food dye en_US
dc.subject Behavioural changes en_US
dc.subject Prenatal stress en_US
dc.subject Hyperactivity en_US
dc.subject Rats en_US
dc.title Lifespan psychomotor behaviour profiles of multigenerational prenatal stress and artificial food dye effects in rats en_US
dc.type Article en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Neuroscience en_US
dc.description.peer-review Yes en_US
dc.publisher.institution University of Lethbridge en_US


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