Show simple item record Shank, Roxanne A. Foroud, Nora A. Hazendonk, Paul Eudes, François Blackwell, Barbara A. 2016-07-05T20:15:11Z 2016-07-05T20:15:11Z 2011
dc.identifier.citation Shank, R.A., Foroud, N.A., Hazendonk, P., Eudes, F., & Blackwell, B.A. (2011). Current and future experimental strategies for structural analysis of trichothecene mycotoxins-a prospectus. Toxins, 3, 1518-1553. doi:10.3390/toxins3121518 en_US
dc.description Open access en_US
dc.description.abstract Fungal toxins, such as those produced by members of the order Hypocreales, have widespread effects on cereal crops, resulting in yield losses and the potential for severe disease and mortality in humans and livestock. Among the most toxic are the trichothecenes. Trichothecenes have various detrimental effects on eukaryotic cells including an interference with protein production and the disruption of nucleic acid synthesis. However, these toxins can have a wide range of toxicity depending on the system. Major differences in the phytotoxicity and cytotoxicity of these mycotoxins are observed for individual members of the class, and variations in toxicity are observed among different species for each individual compound. Furthermore, while diverse toxicological effects are observed throughout the whole cellular system upon trichothecene exposure, the mechanism of toxicity is not well understood. In order to comprehend how these toxins interact with the cell, we must first have an advanced understanding of their structure and dynamics. The structural analysis of trichothecenes was a subject of major interest in the 1980s, and primarily focused on crystallographic and solution-state Nuclear Magnetic Resonance (NMR) spectroscopic studies. Recent advances in structural determination through solution- and solid-state NMR, as well as computation based molecular modeling is leading to a resurgent interest in the structure of these and other mycotoxins, with the focus shifting in the direction of structural dynamics. The purpose of this work is to first provide a brief overview of the structural data available on trichothecenes and a characterization of the methods commonly employed to obtain such information. A summary of the current understanding of the relationship between structure and known function of these compounds is also presented. Finally, a prospectus on the application of new emerging structural methods on these and other related systems is discussed. en_US
dc.language.iso en_CA en_US
dc.publisher M D P I A G en_US
dc.subject Trichothecene en_US
dc.subject NMR en_US
dc.subject Solid-state NMR en_US
dc.subject Crystallography en_US
dc.subject NMR crystallography en_US
dc.subject Natural product en_US
dc.subject Mycotoxin en_US
dc.subject Structure en_US
dc.subject Structure-function en_US
dc.subject Molecular modeling en_US
dc.subject Molecular dynamics en_US
dc.subject Antibiotic en_US
dc.subject Ribosome en_US
dc.title Current and future experimental strategies for structural analysis of trichothecene mycotoxins-a prospectus en_US
dc.type Article en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Chemistry & Biochemistry en_US
dc.description.peer-review Yes en_US
dc.publisher.institution Agriculture and Agri-Food Canada en_US
dc.publisher.institution University of Lethbridge en_US

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