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dc.contributor.supervisor Goater, Cameron P.
dc.contributor.supervisor Colwell, Douglas
dc.contributor.author Phillips, Natalia D.
dc.contributor.author University of Lethbridge. Faculty of Arts and Science
dc.date.accessioned 2016-05-18T22:06:04Z
dc.date.available 2016-05-18T22:06:04Z
dc.date.issued 2016
dc.identifier.uri https://hdl.handle.net/10133/4480
dc.description.abstract Parasitic infections caused by species of gastrointestinal ‘worms’ constrain efficient livestock production through the negative effects they have on individual hosts. Dicrocoelium dendriticum is a host generalist trematode that infects grazing mammals and is an introduced species in Alberta. Reducing the impact of emerging, generalist parasites such as this one requires sensitive and specific diagnosis of individual hosts as well as an understanding of relative host responses to infection. I found high interspecific variation in fluke intensity, fluke recruitment, fecal egg counts, and antibody responses in experimentally infected cattle, sheep, and goats. Fluke intensity was significantly higher in goats (x=257±38) than in sheep (x=132±80) or cattle (x=111±103). Anti-fluke IgG and IgM antibody concentrations were high in sheep sera, but undetectable in cattle sera. A coproantigen ELISA detected D. dendriticum protein in cattle and sheep feces at 9 days post-infection. However, assay sensitivities were poor in sheep (x=45%) and cattle (x=23%). en_US
dc.language.iso en_CA en_US
dc.publisher Lethbridge, Alta : University of Lethbridge, Dept. of Biological Sciences en_US
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en_US
dc.subject coproantigens en_US
dc.subject ELISA en_US
dc.subject enzyme-linked immunosorbent assay en_US
dc.subject host generalist parasites en_US
dc.subject host immune response en_US
dc.title Comparative responses of cattle, sheep, and goats to larvae of the emerging trematode, Dicrocoelium dendriticum, and development of a diagnostic tool en_US
dc.type Thesis en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Biological Sciences en_US
dc.degree.level Masters en_US
dc.proquest.subject 0718 en_US
dc.proquest.subject 0778 en_US
dc.proquest.subject 0982 en_US
dc.proquestyes Yes en_US
dc.embargo No en_US


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