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dc.contributor.supervisor McNaughton, Bruce L.
dc.contributor.author Demchuk, Aubrey Marissa
dc.date.accessioned 2015-01-30T17:56:44Z
dc.date.available 2015-01-30T17:56:44Z
dc.date.issued 2014
dc.identifier.uri https://hdl.handle.net/10133/3637
dc.description.abstract Early immediate-early gene (IEG) studies and electrophysiological data support the “uniform random sample with replacement” (URSWR) model for the orthogonalization of memory representations in the rodent hippocampus. This model is challenged, however, by the observed “preplay” of place cell firing sequences and recent IEG studies that fail to demonstrate the proportionate increase in neuron recruitment predicted to accompany multiple environments. Thus, the purpose of this study was to assess preplay at the molecular level. Utilizing Arc/Homer1a fluorescent in situ hybridization, this study compared patterns of rat neural activity during rest in a familiar environment and during the subsequent exploration of a novel environment. The observed overlap between IEG expression patterns was statistically equivalent to that expected by the URSWR model in both CA1 and CA3 but became significantly higher when analysis was restricted to presumably highly active cells, effectively uniting both the URSWR and preselection models of hippocampal pattern separation. en_US
dc.description.sponsorship Alberta Innovates Health Solutions Polaris Award (to Bruce L. McNaughton) en_US
dc.language.iso en_CA en_US
dc.publisher Lethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience en_US
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en_US
dc.subject spatial memory en_US
dc.subject pattern separation en_US
dc.subject preplay en_US
dc.subject Arc en_US
dc.subject Homer1a en_US
dc.subject hippocampus en_US
dc.title Non-uniform excitability of hippocampal neurons affords weak predictability of future immediate-early gene expression patterns en_US
dc.type Thesis en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Neuroscience en_US
dc.degree.level Masters en_US
dc.degree.level Masters
dc.proquestyes No en_US


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