Non-uniform excitability of hippocampal neurons affords weak predictability of future immediate-early gene expression patterns

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dc.contributor.authorDemchuk, Aubrey M.
dc.contributor.supervisorMcNaughton, Bruce L.
dc.date.accessioned2015-01-30T17:56:44Z
dc.date.available2015-01-30T17:56:44Z
dc.date.issued2014
dc.degree.levelMastersen_US
dc.degree.levelMasters
dc.description.abstractEarly immediate-early gene (IEG) studies and electrophysiological data support the “uniform random sample with replacement” (URSWR) model for the orthogonalization of memory representations in the rodent hippocampus. This model is challenged, however, by the observed “preplay” of place cell firing sequences and recent IEG studies that fail to demonstrate the proportionate increase in neuron recruitment predicted to accompany multiple environments. Thus, the purpose of this study was to assess preplay at the molecular level. Utilizing Arc/Homer1a fluorescent in situ hybridization, this study compared patterns of rat neural activity during rest in a familiar environment and during the subsequent exploration of a novel environment. The observed overlap between IEG expression patterns was statistically equivalent to that expected by the URSWR model in both CA1 and CA3 but became significantly higher when analysis was restricted to presumably highly active cells, effectively uniting both the URSWR and preselection models of hippocampal pattern separation.en_US
dc.description.sponsorshipAlberta Innovates Health Solutions Polaris Award (to Bruce L. McNaughton)en_US
dc.identifier.urihttps://hdl.handle.net/10133/3637
dc.language.isoen_CAen_US
dc.proquestyesNoen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Neuroscienceen_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectspatial memoryen_US
dc.subjectpattern separationen_US
dc.subjectpreplayen_US
dc.subjectArcen_US
dc.subjectHomer1aen_US
dc.subjecthippocampusen_US
dc.titleNon-uniform excitability of hippocampal neurons affords weak predictability of future immediate-early gene expression patternsen_US
dc.typeThesisen_US
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