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dc.contributor.supervisor Inglis, G. Douglas
dc.contributor.author Costa, Estela
dc.contributor.author University of Lethbridge. Faculty of Arts and Science
dc.date.accessioned 2012-03-22T18:45:16Z
dc.date.available 2012-03-22T18:45:16Z
dc.date.issued 2010
dc.identifier.uri https://hdl.handle.net/10133/2627
dc.description xiv, 160 leaves ; 29 cm en_US
dc.description.abstract The novel hypothesis that antimicrobial growth promoters (AGP) function by modulating the mammalian immune system was tested. Sampling methods to characterize the mucosa-associated microbiota of the murine intestine by terminal restriction fragment length polymorphism (T-RFLP) analysis indicated that direct plug extraction was superior to wash methods. Using T-RFLP analysis, non-therapeutic administration of chlortetracycline (CTC) and sulfamethazine to beef cattle did not affect the composition of bacterial communities associated with intestinal mucosa and in digesta, with exception of those associated with mucosa of the proximal jejunum. Similarly, oral administration of non-therapeutic concentrations of CTC did not affect the mucosa-associated microbiota of the murine intestine. Oral administration of nontherapeutic concentrations of CTC prevented weight loss, reduced pathologic changes, modulated transcription levels of inflammatory cytokines in C. rodentium-infected mice, and did not consistently affect the colonic microbiota. These findings support the hypothesis that AGP primarily function by modulating the intestinal immune system. en_US
dc.language.iso en_US en_US
dc.publisher Lethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciences, c2010 en_US
dc.relation.ispartofseries Thesis (University of Lethbridge. Faculty of Arts and Science) en_US
dc.subject Antibiotics in animal nutrition en_US
dc.subject Antibiotic residues -- Health aspects en_US
dc.subject Drug resistance in microorganisms en_US
dc.subject Antibiotics in veterinary medicine en_US
dc.subject Food of animal origin -- Contamination en_US
dc.subject Veterinary drug residues en_US
dc.subject Dissertations, Academic en_US
dc.title Modulation of the immune system in the mammalian intestine as an alternate explanation for the action of antimicrobial growth promoters / Estela Costa en_US
dc.type Thesis en_US
dc.publisher.faculty Arts and Science en_US
dc.publisher.department Department of Biological Sciences en_US


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