Modulation of the immune system in the mammalian intestine as an alternate explanation for the action of antimicrobial growth promoters / Estela Costa

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dc.contributor.authorCosta, Estela
dc.contributor.authorUniversity of Lethbridge. Faculty of Arts and Science
dc.contributor.supervisorInglis, G. Douglas
dc.date.accessioned2012-03-22T18:45:16Z
dc.date.available2012-03-22T18:45:16Z
dc.date.issued2010
dc.descriptionxiv, 160 leaves ; 29 cmen_US
dc.description.abstractThe novel hypothesis that antimicrobial growth promoters (AGP) function by modulating the mammalian immune system was tested. Sampling methods to characterize the mucosa-associated microbiota of the murine intestine by terminal restriction fragment length polymorphism (T-RFLP) analysis indicated that direct plug extraction was superior to wash methods. Using T-RFLP analysis, non-therapeutic administration of chlortetracycline (CTC) and sulfamethazine to beef cattle did not affect the composition of bacterial communities associated with intestinal mucosa and in digesta, with exception of those associated with mucosa of the proximal jejunum. Similarly, oral administration of non-therapeutic concentrations of CTC did not affect the mucosa-associated microbiota of the murine intestine. Oral administration of nontherapeutic concentrations of CTC prevented weight loss, reduced pathologic changes, modulated transcription levels of inflammatory cytokines in C. rodentium-infected mice, and did not consistently affect the colonic microbiota. These findings support the hypothesis that AGP primarily function by modulating the intestinal immune system.en_US
dc.identifier.urihttps://hdl.handle.net/10133/2627
dc.language.isoen_USen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciences, c2010en_US
dc.publisher.departmentDepartment of Biological Sciencesen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectAntibiotics in animal nutritionen_US
dc.subjectAntibiotic residues -- Health aspectsen_US
dc.subjectDrug resistance in microorganismsen_US
dc.subjectAntibiotics in veterinary medicineen_US
dc.subjectFood of animal origin -- Contaminationen_US
dc.subjectVeterinary drug residuesen_US
dc.subjectDissertations, Academicen_US
dc.titleModulation of the immune system in the mammalian intestine as an alternate explanation for the action of antimicrobial growth promoters / Estela Costaen_US
dc.typeThesisen_US
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