Characterization of Mannheimia haemolytica-specific bacteriophages

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dc.contributor.authorHsu, Yu-Hung
dc.contributor.supervisorSelinger, L. Brent
dc.contributor.supervisorMcAllister, Tim A.
dc.date.accessioned2012-10-04T22:04:23Z
dc.date.available2012-10-04T22:04:23Z
dc.date.issued2011
dc.degree.levelMasters
dc.descriptionviii, 107 leaves : ill. ; 29 cmen_US
dc.description.abstractMannheimia haemolytica is the principal bacterial agent associated with bovine respiratory disease (BRD). It has a significant economic impact on the beef feedlot industry. The current methods for BRD prevention and treatment have various problems and limitations, especially with reports of increased antimicrobial resistance in M. haemolytica. Bacteriophage therapy presents a novel method to mitigate M. haemolytica. This study aimed to isolate strictly lytic M. haemolytica-specific bacteriophages from bovine nasopharyngeal swabs and feedlot trough water. This was accompanied by an extensive characterization of temperate bacteriophages induced from representative strains of a M. haemolytica collection. Phage morphology, host specificity, genomic diversity, and comparative genomics were determined. Even though temperate bacteriophages are not ideal candidates for phage therapy, they can be engineered or modified to serve this function. Genome sequences of selected temperate bacteriophages also provide a foundation for future studies on the biology of these microorganisms.en_US
dc.identifier.urihttps://hdl.handle.net/10133/3150
dc.language.isoen_USen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Biological Sciences, c2011en_US
dc.publisher.departmentDepartment of Biological Sciencesen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectBacteriophages -- Geneticsen_US
dc.subjectBacteriophages -- Researchen_US
dc.subjectBacteriophages -- Therapeutic useen_US
dc.subjectBovine pneumonic pasteurellosis -- Treatment -- Researchen_US
dc.subjectBovine pneumonic pasteurellosis -- Prevention -- Researchen_US
dc.subjectCommunicable diseases in animals -- Treatment -- Researchen_US
dc.subjectDissertations, Academicen_US
dc.titleCharacterization of Mannheimia haemolytica-specific bacteriophagesen_US
dc.typeThesisen_US
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