Conformational analysis of trichothecene mycotoxins : a solution- and solid-state nuclear magnetic resonance (NMR) study

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dc.contributor.authorShank, Roxanne Angela
dc.contributor.supervisorHazendonk, Paul
dc.contributor.supervisorEudes, François
dc.date.accessioned2014-10-08T18:33:28Z
dc.date.available2014-10-08T18:33:28Z
dc.date.issued2014
dc.degree.levelMastersen_US
dc.degree.levelMasters
dc.description.abstractTrichothecenes comprise a large family of sesquiterpenoidal mycotoxins that largely effect the production of cereal crops. Recent advances in structural determination through solution- and solid-state NMR provide new avenues to the understanding of the structural dynamics of these toxins. Refinement of the proton and carbon assignments in deuterated chloroform (CDCl3) are presented for the type A trichothecene T-2 toxin, and the type B trichothecenes deoxynivalenol (DON), nivalenol (NIV), 3-O-acetyldeoxynivalenol (3-ADON), and 15-O-acetyldeoxynivalenol (15-ADON). The effect of different solvent systems on the type B trichothecenes is investigated, and evidence for structural isomerism of the trichothecenes is presented. The mechanism for the rearrangement between the two isomers is presented. Solid-state NMR investigations demonstrate multiple configurations for T-2 toxin, and structural isomerism is shown to exist in the sold-state for DON. Solution- and solid-state NMR data was used to determine the interaction of water with selected trichothecenes, and the water-binding interactions are described.en_US
dc.identifier.urihttps://hdl.handle.net/10133/3521
dc.language.isoen_CAen_US
dc.proquest.subject0359en_US
dc.proquest.subject0490en_US
dc.proquest.subject0473en_US
dc.proquestyesYesen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Chemistry and Biochemistryen_US
dc.publisher.departmentDepartment of Chemistry and Biochemistryen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectTrichotheceneen_US
dc.subjectNMRen_US
dc.subjectMagnetic Resonanceen_US
dc.subjectSolid-State NMRen_US
dc.subjectToxinen_US
dc.subjectMycotoxinen_US
dc.subjectAgricultureen_US
dc.subjectFusarium Head Blighten_US
dc.subjectDeoxynivalenolen_US
dc.subjectT2 Toxinen_US
dc.subjectNivalenolen_US
dc.subjectRibosomeen_US
dc.titleConformational analysis of trichothecene mycotoxins : a solution- and solid-state nuclear magnetic resonance (NMR) studyen_US
dc.typeThesisen_US
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