Modulation of compensation and recovery in a rat model of motor cortex stroke : implications of transcranial direct current stimulation

Simple item page
dc.contributor.authorGidyk, Darryl C.
dc.contributor.supervisorSutherland, Robert J.
dc.date.accessioned2013-01-18T20:27:55Z
dc.date.available2013-01-18T20:27:55Z
dc.date.issued2011
dc.degree.levelMasters
dc.descriptionix, 75 leaves : col. ill. ; 29 cmen_US
dc.description.abstractThe present thesis examines the effects of transcranial direct current stimulation and forelimb rehabilitation on motor recovery after stroke in rats. Post-stroke motor outcomes were quantified using an innovative battery of behavioural tests and high resolution, in vivo electrophysiology was employed to examine coherence of neural activity between hemispheres. It was shown that rats that received brain stimulation concurrently with forelimb rehabilitation displayed functional recovery, whereas rats that received rehabilitation alone partially regained motor function, but the improvements were not due to restitution of original movement patterns. Results from electrophysiological recordings showed that rats that received brain stimulation and rehabilitation regained pre-stroke levels of interhemispheric coherence, but rats that received rehabilitation alone did not. The present thesis suggests that transcranial direct current stimulation may be a viable adjunct therapy to increase the efficacy of physical rehabilitation with regard to post-stroke motor outcomes. Interhemishperic coherence between homotopic neuronal populations may represent a biomarker of genuine motor recovery after stroke.en_US
dc.identifier.urihttps://hdl.handle.net/10133/3236
dc.language.isoen_USen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Neuroscience, c2011en_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectCerebrovascular disease -- Researchen_US
dc.subjectCerebrovascular disease -- Rehabilitationen_US
dc.subjectBrain stimulation -- Therapeutic useen_US
dc.subjectBrain stimulation -- Researchen_US
dc.subjectBrain stimulation -- Animal modelsen_US
dc.subjectPhysical therapy -- Therapeutic useen_US
dc.subjectPhysical therapy -- Animal modelsen_US
dc.subjectNeuroplasticity -- Researchen_US
dc.subjectRats as laboratory animalsen_US
dc.subjectDissertations, Academicen_US
dc.titleModulation of compensation and recovery in a rat model of motor cortex stroke : implications of transcranial direct current stimulationen_US
dc.typeThesisen_US
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
GIDYK_DARRYL_MSC_2011.pdf
Size:
2.27 MB
Format:
Adobe Portable Document Format
Description:
Download
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.63 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Arts and Science, Faculty of
University of Lethbridge Theses