Maternal stress induces eipgenetic signatures of psychiatric and neurological diseases in the offspring

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dc.contributor.authorZucchi, Fabiola C. R.
dc.contributor.authorYao, Youli
dc.contributor.authorWard, Isaac D.
dc.contributor.authorIlnytskyy, Yaroslav
dc.contributor.authorOlson, David M.
dc.contributor.authorBenzies, Karen
dc.contributor.authorKovalchuk, Igor
dc.contributor.authorKovalchuk, Olga
dc.contributor.authorMetz, Gerlinde A. S.
dc.date.accessioned2016-11-02T16:52:52Z
dc.date.available2016-11-02T16:52:52Z
dc.date.issued2013
dc.descriptionSherpa Romeo green journal: open accessen_US
dc.description.abstractThe gestational state is a period of particular vulnerability to diseases that affect maternal and fetal health. Stress during gestation may represent a powerful influence on maternal mental health and offspring brain plasticity and development. Here we show that the fetal transcriptome, through microRNA (miRNA) regulation, responds to prenatal stress in association with epigenetic signatures of psychiatric and neurological diseases. Pregnant Long-Evans rats were assigned to stress from gestational days 12 to 18 while others served as handled controls. Gestational stress in the dam disrupted parturient maternal behaviour and was accompanied by characteristic brain miRNA profiles in the mother and her offspring, and altered transcriptomic brain profiles in the offspring. In the offspring brains, prenatal stress upregulated miR-103, which is involved in brain pathologies, and downregulated its potential gene target Ptplb. Prenatal stress downregulated miR-145, a marker of multiple sclerosis in humans. Prenatal stress also upregulated miR-323 and miR-98, which may alter inflammatory responses in the brain. Furthermore, prenatal stress upregulated miR-219, which targets the gene Dazap1. Both miR-219 and Dazap1 are putative markers of schizophrenia and bipolar affective disorder in humans. Offspring transcriptomic changes included genes related to development, axonal guidance and neuropathology. These findings indicate that prenatal stress modifies epigenetic signatures linked to disease during critical periods of fetal brain development. These observations provide a new mechanistic association between environmental and genetic risk factors in psychiatric and neurological disease.en_US
dc.description.peer-reviewYesen_US
dc.identifier.citationZucchi, F.C. R., Yao, Y., Ward, I. D., Ilnytskyy, Y., Olson, D. M., Benzies, K., ... Metz, G. A. S. (2013). Maternal stress induces epigenetic signatures of psychiatric and neurological diseases of the offspring. PLoS ONE 8(2), e56967. doi:10.1371.journal.pone.0056967en_US
dc.identifier.urihttps://hdl.handle.net/10133/4644
dc.language.isoen_CAen_US
dc.publisherPublic Library of Scienceen_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.departmentDepartment of Biological Sciencesen_US
dc.publisher.facultyArts and Scienceen_US
dc.publisher.institutionUniversity of Lethbridgeen_US
dc.publisher.institutionUniversity of Mato Grosso Stateen_US
dc.publisher.institutionUniversity of Albertaen_US
dc.publisher.institutionUniversity of Calgaryen_US
dc.subjectGestational stressen_US
dc.subjectPrenatal stressen_US
dc.subjectEpigenetic signaturesen_US
dc.subjectOffspringen_US
dc.subjectPsychiatric diseaseen_US
dc.subjectNeurological diseaseen_US
dc.subjectFetal brain developmenten_US
dc.titleMaternal stress induces eipgenetic signatures of psychiatric and neurological diseases in the offspringen_US
dc.typeArticleen_US
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Kovalchuk, Igor
Kovalchuk, Olga
Metz, Gerlinde