Kinetic analyses on two translational GTPases : LepA and EF-Tu

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dc.contributor.authorDe Laurentiis, Evelina I.
dc.contributor.supervisorWieden, Hans-Joachim
dc.date.accessioned2014-06-06T20:28:49Z
dc.date.available2014-06-06T20:28:49Z
dc.date.issued2013
dc.degree.levelPh.Den_US
dc.degree.levelPhD
dc.descriptionxiii, 177 leaves : col. ill. ; 29 cmen_US
dc.description.abstractProtein synthesis is an essential process for all living organisms and is an effective major target for current antibiotics. Elongation factor Tu (EF-Tu) is a highly conserved and essential protein that functions during protein synthesis. EF-Ts interacts with EF-Tu to help maintain a functionally active state of EF-Tu required for cell growth. Although EF-Ts is essential for Escherichia coli, its sequence is poorly conserved. LepA is a highly conserved protein within bacteria and has a similar structure to EF-Tu. In spite of this, LepA has been shown to be non-essential under ideal conditions and the function of LepA still remains elusive. An analysis on the structurally unique aspects of LepA, EF-Tu and EF-Ts was performed here in an effort to gain an understanding on the functions of these proteins. This knowledge, in combination with their unique structural components will provide important tools in developing new and effective antibiotics.en_US
dc.identifier.urihttps://hdl.handle.net/10133/3450
dc.language.isoen_CAen_US
dc.proquestyesNoen_US
dc.publisherLethbridge, Alta. : University of Lethbridge, Dept. of Chemistry and Biochemistryen_US
dc.publisher.departmentDepartment of Chemistry and Biochemistryen_US
dc.publisher.facultyArts and Scienceen_US
dc.relation.ispartofseriesThesis (University of Lethbridge. Faculty of Arts and Science)en_US
dc.subjectGuanosine triphosphataseen_US
dc.subjectSignal peptidasesen_US
dc.subjectGenetic translationen_US
dc.subjectProteins -- Synthesisen_US
dc.titleKinetic analyses on two translational GTPases : LepA and EF-Tuen_US
dc.typeThesisen_US
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