Hippocampus leads ventral striatum in reply of place-reward information

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Lansink, Carien S.
Goltstein, Pieter M.
Lankelma, Jan V.
McNaughton, Bruce L.
Pennartz, Cyriel M. A.
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Public Library of Science
Associating spatial locations with rewards is fundamental to survival in natural environments and requires the integrity of the hippocampus and ventral striatum. In joint multineuron recordings from these areas, hippocampal–striatal ensembles reactivated together during sleep. This process was especially strong in pairs in which the hippocampal cell processed spatial information and ventral striatal firing correlated to reward. Replay was dominated by cell pairs in which the hippocampal ‘‘place’’ cell fired preferentially before the striatal reward-related neuron. Our results suggest a plausible mechanism for consolidating place-reward associations and are consistent with a central tenet of consolidation theory, showing that the hippocampus leads reactivation in a projection area.
Sherpa Romeo green journal: open access
Hippocampus (Brain) , Ventral striatum , Place-reward associations , Sleep
Lansink, C. S., Golstein, P. M., Lankelma, J. V., McNaughton, B. L., & Pennartz, C. M. A. (2009). Hippocampus leads ventral stiatum in reply of place-reward information. PLoS Biology, 7(8): e1000173. doi:10.1371/journal.pbio.1000173