Hippocampus leads ventral striatum in reply of place-reward information
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Date
2009
Authors
Lansink, Carien S.
Goltstein, Pieter M.
Lankelma, Jan V.
McNaughton, Bruce L.
Pennartz, Cyriel M. A.
Journal Title
Journal ISSN
Volume Title
Publisher
Public Library of Science
Abstract
Associating spatial locations with rewards is fundamental to survival in natural environments and requires the integrity of
the hippocampus and ventral striatum. In joint multineuron recordings from these areas, hippocampal–striatal ensembles
reactivated together during sleep. This process was especially strong in pairs in which the hippocampal cell processed
spatial information and ventral striatal firing correlated to reward. Replay was dominated by cell pairs in which the
hippocampal ‘‘place’’ cell fired preferentially before the striatal reward-related neuron. Our results suggest a plausible
mechanism for consolidating place-reward associations and are consistent with a central tenet of consolidation theory,
showing that the hippocampus leads reactivation in a projection area.
Description
Sherpa Romeo green journal: open access
Keywords
Hippocampus (Brain) , Ventral striatum , Place-reward associations , Sleep
Citation
Lansink, C. S., Golstein, P. M., Lankelma, J. V., McNaughton, B. L., & Pennartz, C. M. A. (2009). Hippocampus leads ventral stiatum in reply of place-reward information. PLoS Biology, 7(8): e1000173. doi:10.1371/journal.pbio.1000173