Hippocampus leads ventral striatum in reply of place-reward information

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dc.contributor.authorLansink, Carien S.
dc.contributor.authorGoltstein, Pieter M.
dc.contributor.authorLankelma, Jan V.
dc.contributor.authorMcNaughton, Bruce L.
dc.contributor.authorPennartz, Cyriel M. A.
dc.date.accessioned2017-02-28T23:46:28Z
dc.date.available2017-02-28T23:46:28Z
dc.date.issued2009
dc.descriptionSherpa Romeo green journal: open accessen_US
dc.description.abstractAssociating spatial locations with rewards is fundamental to survival in natural environments and requires the integrity of the hippocampus and ventral striatum. In joint multineuron recordings from these areas, hippocampal–striatal ensembles reactivated together during sleep. This process was especially strong in pairs in which the hippocampal cell processed spatial information and ventral striatal firing correlated to reward. Replay was dominated by cell pairs in which the hippocampal ‘‘place’’ cell fired preferentially before the striatal reward-related neuron. Our results suggest a plausible mechanism for consolidating place-reward associations and are consistent with a central tenet of consolidation theory, showing that the hippocampus leads reactivation in a projection area.en_US
dc.description.peer-reviewYesen_US
dc.identifier.citationLansink, C. S., Golstein, P. M., Lankelma, J. V., McNaughton, B. L., & Pennartz, C. M. A. (2009). Hippocampus leads ventral stiatum in reply of place-reward information. PLoS Biology, 7(8): e1000173. doi:10.1371/journal.pbio.1000173en_US
dc.identifier.urihttps://hdl.handle.net/10133/4786
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.publisher.departmentDepartment of Neuroscienceen_US
dc.publisher.facultyArts and Scienceen_US
dc.publisher.institutionUniversity of Amsterdamen_US
dc.publisher.institutionUniversity of Lethbridgeen_US
dc.subjectHippocampus (Brain)en_US
dc.subjectVentral striatumen_US
dc.subjectPlace-reward associationsen_US
dc.subjectSleepen_US
dc.titleHippocampus leads ventral striatum in reply of place-reward informationen_US
dc.typeArticleen_US
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